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Structural basis for interdomain communication in SHIP2 providing high phosphatase activity

SH2-containing-inositol-5-phosphatases (SHIPs) dephosphorylate the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P(3)) and play important roles in regulating the PI3K/Akt pathway in physiology and disease. Aiming to uncover interdomain regulatory mechanisms in SHIP2, we determine...

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Detalles Bibliográficos
Autores principales:	Le Coq, Johanne, Camacho-Artacho, Marta, Velázquez, José Vicente, Santiveri, Clara M, Gallego, Luis Heredia, Campos-Olivas, Ramón, Dölker, Nicole, Lietha, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550278/ https://www.ncbi.nlm.nih.gov/pubmed/28792888 http://dx.doi.org/10.7554/eLife.26640

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