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Design of Elastic Networks with Evolutionary Optimized Long-Range Communication as Mechanical Models of Allosteric Proteins
Allosteric effects often underlie the activity of proteins, and elucidating generic design aspects and functional principles unique to allosteric phenomena represent a major challenge. Here an approach consisting of the in silico design of synthetic structures, which, as the principal element of all...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Biophysical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550307/ https://www.ncbi.nlm.nih.gov/pubmed/28793211 http://dx.doi.org/10.1016/j.bpj.2017.06.043 |