Impaired lymphocyte trafficking in mice deficient in the kinase activity of PKN1

Knock-in mice lacking PKN1 kinase activity were generated by introducing a T778A point mutation in the catalytic domain. PKN1[T778A] mutant mice developed to adulthood without apparent external abnormalities, but exhibited lower T and B lymphocyte counts in the peripheral blood than those of wild-ty...

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Detalles Bibliográficos
Autores principales: Mashud, Rana, Nomachi, Akira, Hayakawa, Akihide, Kubouchi, Koji, Danno, Sally, Hirata, Takako, Matsuo, Kazuhiko, Nakayama, Takashi, Satoh, Ryosuke, Sugiura, Reiko, Abe, Manabu, Sakimura, Kenji, Wakana, Shigeharu, Ohsaki, Hiroyuki, Kamoshida, Shingo, Mukai, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550459/
https://www.ncbi.nlm.nih.gov/pubmed/28794483
http://dx.doi.org/10.1038/s41598-017-07936-9

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