Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

In neurodegenerative diseases, seeding is a process initiated by the internalization of exogenous protein aggregates. Multiple pathways for internalization of aggregates have been proposed, including direct membrane penetration and endocytosis. To decipher the seeding mechanisms of alpha-synuclein (...

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Detalles Bibliográficos
Autores principales: Jiang, Peizhou, Gan, Ming, Yen, Shu-Hui, McLean, Pamela J., Dickson, Dennis W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550496/
https://www.ncbi.nlm.nih.gov/pubmed/28794446
http://dx.doi.org/10.1038/s41598-017-08149-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550496/
https://www.ncbi.nlm.nih.gov/pubmed/28794446
http://dx.doi.org/10.1038/s41598-017-08149-w

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