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Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates
In neurodegenerative diseases, seeding is a process initiated by the internalization of exogenous protein aggregates. Multiple pathways for internalization of aggregates have been proposed, including direct membrane penetration and endocytosis. To decipher the seeding mechanisms of alpha-synuclein (...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550496/ https://www.ncbi.nlm.nih.gov/pubmed/28794446 http://dx.doi.org/10.1038/s41598-017-08149-w |