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Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation

During obesity, macrophages can infiltrate metabolic tissues, and contribute to chronic low-grade inflammation, and mediate insulin resistance and diabetes. Recent studies have elucidated the metabolic role of JAK2, a key mediator downstream of various cytokines and growth factors. Our study address...

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Detalles Bibliográficos
Autores principales:	Desai, Harsh R., Sivasubramaniyam, Tharini, Revelo, Xavier S., Schroer, Stephanie A., Luk, Cynthia T., Rikkala, Prashanth R., Metherel, Adam H., Dodington, David W., Park, Yoo Jin, Kim, Min Jeong, Rapps, Joshua A., Besla, Rickvinder, Robbins, Clinton S., Wagner, Kay-Uwe, Bazinet, Richard P., Winer, Daniel A., Woo, Minna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550513/ https://www.ncbi.nlm.nih.gov/pubmed/28794431 http://dx.doi.org/10.1038/s41598-017-07923-0

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