Cargando…
The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
Inflammatory responses play a key role in many neural pathologies, with localized signaling from the non-immune cells making critical contributions. The NLRP3 inflammasome is an important component of innate immune signaling and can link neural insult to chronic inflammation. The NLRP3 inflammasome...
Autores principales: | Albalawi, Farraj, Lu, Wennan, Beckel, Jonathan M., Lim, Jason C., McCaughey, Stuart A., Mitchell, Claire H. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550720/ https://www.ncbi.nlm.nih.gov/pubmed/28848393 http://dx.doi.org/10.3389/fncel.2017.00227 |
Ejemplares similares
-
Stimulation of TLR3 triggers release of lysosomal ATP in astrocytes and epithelial cells that requires TRPML1 channels
por: Beckel, Jonathan M., et al.
Publicado: (2018) -
Neuronal Release of Cytokine IL-3 Triggered by Mechanosensitive Autostimulation of the P2X7 Receptor Is Neuroprotective
por: Lim, Jason C., et al.
Publicado: (2016) -
NLRP3 Inflammasome Priming and Activation Are Regulated by a Phosphatidylinositol-Dependent Mechanism
por: Hamilton, Claire, et al.
Publicado: (2022) -
Doxycycline Attenuates Leptospira-Induced IL-1β by Suppressing NLRP3 Inflammasome Priming
por: Zhang, Wenlong, et al.
Publicado: (2017) -
Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages
por: Hoyle, Christopher, et al.
Publicado: (2022)