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Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan
AIM: To investigate whether single nucleotide polymorphisms in maf protein K (MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. METHODS: This case control study examined the associations between MAFK single nucleotide polymorphisms (rs4...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550785/ https://www.ncbi.nlm.nih.gov/pubmed/28839436 http://dx.doi.org/10.3748/wjg.v23.i29.5364 |
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author | Arisawa, Tomiyasu Nakamura, Masakatsu Otsuka, Toshimi Jing, Wu Sakurai, Naoko Takano, Hikaru Hayashi, Tasuku Ota, Masafumi Nomura, Tomoe Hayashi, Ranji Shimasaki, Takeo Tahara, Tomomitsu Shibata, Tomoyuki |
author_facet | Arisawa, Tomiyasu Nakamura, Masakatsu Otsuka, Toshimi Jing, Wu Sakurai, Naoko Takano, Hikaru Hayashi, Tasuku Ota, Masafumi Nomura, Tomoe Hayashi, Ranji Shimasaki, Takeo Tahara, Tomomitsu Shibata, Tomoyuki |
author_sort | Arisawa, Tomiyasu |
collection | PubMed |
description | AIM: To investigate whether single nucleotide polymorphisms in maf protein K (MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. METHODS: This case control study examined the associations between MAFK single nucleotide polymorphisms (rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis (UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia (controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings (IBM controls). RESULTS: The genotype frequency of rs4268033 AA and allelic frequency of the rs4268033A allele were significantly higher in the UC cases than in both controls (P = 0.0005 and < 0.0001, P = 0.015 and 0.0027 vs controls and IBM controls, respectively). Logistic regression analysis after adjustment for age and gender showed that the rs4268033 AA and rs3735656 CC genotypes were significantly associated with susceptibility to UC development (OR = 2.63, 95%CI: 1.61-4.30, P = 0.0001 and OR = 1.81; 95%CI: 1.12-2.94, P = 0.015, respectively). Similar findings were observed by the comparison with IBM controls. In addition, the rs4268033 AA genotype was significantly associated with all phenotypes of UC except early onset. There was no significant association between rs10226620 and ulcerative colitis. CONCLUSION: Our results provide the first evidence that MAFK genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC. |
format | Online Article Text |
id | pubmed-5550785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-55507852017-08-24 Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan Arisawa, Tomiyasu Nakamura, Masakatsu Otsuka, Toshimi Jing, Wu Sakurai, Naoko Takano, Hikaru Hayashi, Tasuku Ota, Masafumi Nomura, Tomoe Hayashi, Ranji Shimasaki, Takeo Tahara, Tomomitsu Shibata, Tomoyuki World J Gastroenterol Case Control Study AIM: To investigate whether single nucleotide polymorphisms in maf protein K (MAFK), which encodes the MAFK, lead to increased susceptibility to ulcerative colitis in the Japanese population. METHODS: This case control study examined the associations between MAFK single nucleotide polymorphisms (rs4268033 G>A, rs3735656 T>C and rs10226620 C>T) and ulcerative colitis susceptibility in 174 patients with ulcerative colitis (UC) cases, and 748 subjects without no lower abdominal symptoms, diarrhea or hematochezia (controls). In addition, as the second controls, we set 360 subjects, who have an irregular bowel movement without abnormal lower endoscopic findings (IBM controls). RESULTS: The genotype frequency of rs4268033 AA and allelic frequency of the rs4268033A allele were significantly higher in the UC cases than in both controls (P = 0.0005 and < 0.0001, P = 0.015 and 0.0027 vs controls and IBM controls, respectively). Logistic regression analysis after adjustment for age and gender showed that the rs4268033 AA and rs3735656 CC genotypes were significantly associated with susceptibility to UC development (OR = 2.63, 95%CI: 1.61-4.30, P = 0.0001 and OR = 1.81; 95%CI: 1.12-2.94, P = 0.015, respectively). Similar findings were observed by the comparison with IBM controls. In addition, the rs4268033 AA genotype was significantly associated with all phenotypes of UC except early onset. There was no significant association between rs10226620 and ulcerative colitis. CONCLUSION: Our results provide the first evidence that MAFK genetic polymorphisms are significantly associated with susceptibility to UC development. In particular, rs4268033 is closely associated with an increased risk for the development of UC. Baishideng Publishing Group Inc 2017-08-07 2017-08-07 /pmc/articles/PMC5550785/ /pubmed/28839436 http://dx.doi.org/10.3748/wjg.v23.i29.5364 Text en ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Case Control Study Arisawa, Tomiyasu Nakamura, Masakatsu Otsuka, Toshimi Jing, Wu Sakurai, Naoko Takano, Hikaru Hayashi, Tasuku Ota, Masafumi Nomura, Tomoe Hayashi, Ranji Shimasaki, Takeo Tahara, Tomomitsu Shibata, Tomoyuki Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan |
title | Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan |
title_full | Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan |
title_fullStr | Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan |
title_full_unstemmed | Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan |
title_short | Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan |
title_sort | genetic polymorphisms of mafk, encoding a small maf protein, are associated with susceptibility to ulcerative colitis in japan |
topic | Case Control Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550785/ https://www.ncbi.nlm.nih.gov/pubmed/28839436 http://dx.doi.org/10.3748/wjg.v23.i29.5364 |
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