Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy

To examine the temporal relationship of cortical autophagic flux with delayed neuronal cell death after hypoxia-ischemia (HI) in neonatal piglets. HI was produced with 45-min hypoxia and 7-min airway occlusion in 3–5-day-old piglets. Markers of autophagic, lysosomal and cell death signaling were stu...

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Detalles Bibliográficos
Autores principales: Cui, Derong, Sun, Dawei, Wang, Xintao, Yi, Liye, Kulikowicz, Ewa, Reyes, Michael, Zhu, Junchao, Yang, Zeng-Jin, Jiang, Wei, Koehler, Raymond C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550864/
https://www.ncbi.nlm.nih.gov/pubmed/28703794
http://dx.doi.org/10.1038/cddis.2017.318

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