Cargando…

Neuroprotection by eIF2α-CHOP inhibition and XBP-1 activation in EAE/optic neuritiss

No therapies exist to prevent neuronal deficits in multiple sclerosis (MS), because the molecular mechanism responsible for the progressive neurodegeneration is unknown. We previously showed that axon injury-induced neuronal endoplasmic reticulum (ER) stress plays an important role in retinal gangli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Haoliang, Miao, Linqing, Liang, Feisi, Liu, Xiaodong, Xu, Lin, Teng, Xiuyin, Wang, Qizhao, Ridder, William H, Shindler, Kenneth S, Sun, Yang, Hu, Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550873/ https://www.ncbi.nlm.nih.gov/pubmed/28726788 http://dx.doi.org/10.1038/cddis.2017.329

Ejemplares similares

The mTORC1 Effectors S6K1 and 4E-BP Play Different Roles in CNS Axon Regeneration
por: Yang, Liu, et al.
Publicado: (2014)

AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration
por: Huang, Haoliang, et al.
Publicado: (2019)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

PCV2 and PRV Coinfection Induces Endoplasmic Reticulum Stress via PERK-eIF2α-ATF4-CHOP and IRE1-XBP1-EDEM Pathways
por: Chen, Si, et al.
Publicado: (2022)

eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus
por: Li, Yanrong, et al.
Publicado: (2019)

Differential effects of SARM1 inhibition in traumatic glaucoma and EAE optic neuropathies
por: Liu, Pingting, et al.
Publicado: (2023)

ERH Interacts With EIF2α and Regulates the EIF2α/ATF4/CHOP Pathway in Bladder Cancer Cells
por: Pang, Kun, et al.
Publicado: (2022)

Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions
por: Chen, Yi-Jiun, et al.
Publicado: (2010)

MANF Is Neuroprotective in Early Stages of EAE, and Elevated in Spinal White Matter by Treatment With Dexamethasone
por: Nam, Jinhan, et al.
Publicado: (2021)

Melatonin promotes sirtuin 1 expression and inhibits IRE1α–XBP1S–CHOP to reduce endoplasmic reticulum stress–mediated apoptosis in chondrocytes
por: Qin, Kunpeng, et al.
Publicado: (2022)

CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE
por: Wlodarczyk, Agnieszka, et al.
Publicado: (2019)

Dexras1 Deletion and Iron Chelation Promote Neuroprotection in Experimental Optic Neuritis
por: Khan, Reas S., et al.
Publicado: (2019)

RGC Neuroprotection Following Optic Nerve Trauma Mediated By Intranasal Delivery of Amnion Cell Secretome
por: Grinblat, Gabriela A., et al.
Publicado: (2018)

Ligustilide Improves Cognitive Impairment via Regulating the SIRT1/IRE1α/XBP1s/CHOP Pathway in Vascular Dementia Rats
por: Peng, Dong, et al.
Publicado: (2022)

PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription
por: Lew, Qiao Jing, et al.
Publicado: (2011)

Role of the PERK-eIF2α-CHOP Signaling Pathway in the Effect of Needle Knife Therapy on Knee Joint Chondrocyte Apoptosis
por: Yang, Yong-hui, et al.
Publicado: (2019)

Rethinking EAE pathogenesis
por: Van Epps, Heather L.
Publicado: (2005)

PARing down EAE
por: Van Epps, Heather L.
Publicado: (2006)

RGC-specific ATF4 and/or CHOP deletion rescues glaucomatous neurodegeneration and visual function
por: Fang, Fang, et al.
Publicado: (2023)

Knockdown of NUPR1 inhibits angiogenesis in lung cancer through IRE1/XBP1 and PERK/eIF2α/ATF4 signaling pathways
por: Wang, Lihuai, et al.
Publicado: (2023)

PERK‐eIF2α‐ATF4‐CHOP Signaling Contributes to TNFα‐Induced Vascular Calcification
por: Masuda, Masashi, et al.
Publicado: (2013)

Avarol Induces Apoptosis in Pancreatic Ductal Adenocarcinoma Cells by Activating PERK–eIF2α–CHOP Signaling
por: Namba, Takushi, et al.
Publicado: (2015)

NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK–eIF2α–ATF4 signalling in breast cancer
por: Gupta, A, et al.
Publicado: (2016)

Thomas Rivers and the EAE model
por: Van Epps, Heather L.
Publicado: (2005)

Role of Microglia and Macrophages in Eae
por: Raivich, Gennadij, et al.
Publicado: (2005)

Neuronal NMNAT2 Overexpression Does Not Achieve Significant Neuroprotection in Experimental Autoimmune Encephalomyelitis/Optic Neuritis
por: Liu, Pingting, et al.
Publicado: (2021)

Curcumin Inhibits the PERK-eIF2α-CHOP Pathway through Promoting SIRT1 Expression in Oxidative Stress-induced Rat Chondrocytes and Ameliorates Osteoarthritis Progression in a Rat Model
por: Feng, Kai, et al.
Publicado: (2019)

XBP-1 image overhaul
por: Van Epps, Heather L.
Publicado: (2005)

EGFR confers radioresistance in human oropharyngeal carcinoma by activating endoplasmic reticulum stress signaling PERK‐eIF2α‐GRP94 and IRE1α‐XBP1‐GRP78
por: Zhang, Miao, et al.
Publicado: (2018)

Saturated Fatty Acids Promote GDF15 Expression in Human Macrophages through the PERK/eIF2/CHOP Signaling Pathway
por: L’homme, Laurent, et al.
Publicado: (2020)

Sinulariolide Induced Hepatocellular Carcinoma Apoptosis through Activation of Mitochondrial-Related Apoptotic and PERK/eIF2α/ATF4/CHOP Pathway
por: Chen, Yi-Jen, et al.
Publicado: (2013)

SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis
por: McDougald, Devin S., et al.
Publicado: (2018)

The Immunomodulatory and Neuroprotective Effects of Mesenchymal Stem Cells (MSCs) in Experimental Autoimmune Encephalomyelitis (EAE): A Model of Multiple Sclerosis (MS)
por: Al Jumah, Mohammed A., et al.
Publicado: (2012)

NLRP3 Inflammasome and MS/EAE
por: Inoue, Makoto, et al.
Publicado: (2013)

The EAES intellectual property awareness survey
por: Nakajima, Kiyokazu, et al.
Publicado: (2021)

Overexpression of GSN could decrease inflammation and apoptosis in EAE and may enhance vitamin D therapy on EAE/MS
por: Gao, Jifang, et al.
Publicado: (2017)

Toll-like receptor activation suppresses endoplasmic reticulum stress-induced CHOP and translation inhibition through activation of eIF2B
por: Woo, Connie W., et al.
Publicado: (2012)

The Role of XBP1 in bone metabolism
por: Lv, Wenhao, et al.
Publicado: (2023)

pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
por: Yoshida, Hiderou, et al.
Publicado: (2006)

RAM-589.555 favors neuroprotective and anti-inflammatory profile of CNS-resident glial cells in acute relapse EAE affected mice
por: Zilkha-Falb, Rina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_tnbpukd3kcpk4tk621msopnsjv