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Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions

BACKGROUND: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). METHODS: The study includes 213 ICU patients with clini...

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Autores principales: Hamed, Sonja, Behnes, Michael, Pauly, Dominic, Lepiorz, Dominic, Barre, Max, Becher, Tobias, Lang, Siegfried, Akin, Ibrahim, Borggrefe, Martin, Bertsch, Thomas, Hoffmann, Ursula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550951/
https://www.ncbi.nlm.nih.gov/pubmed/28793880
http://dx.doi.org/10.1186/s12879-017-2606-3
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author Hamed, Sonja
Behnes, Michael
Pauly, Dominic
Lepiorz, Dominic
Barre, Max
Becher, Tobias
Lang, Siegfried
Akin, Ibrahim
Borggrefe, Martin
Bertsch, Thomas
Hoffmann, Ursula
author_facet Hamed, Sonja
Behnes, Michael
Pauly, Dominic
Lepiorz, Dominic
Barre, Max
Becher, Tobias
Lang, Siegfried
Akin, Ibrahim
Borggrefe, Martin
Bertsch, Thomas
Hoffmann, Ursula
author_sort Hamed, Sonja
collection PubMed
description BACKGROUND: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). METHODS: The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. RESULTS: PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). CONCLUSION: PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. TRIAL REGISTRATION: NCT01535534. Registered 14.02.2012
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spelling pubmed-55509512017-08-14 Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions Hamed, Sonja Behnes, Michael Pauly, Dominic Lepiorz, Dominic Barre, Max Becher, Tobias Lang, Siegfried Akin, Ibrahim Borggrefe, Martin Bertsch, Thomas Hoffmann, Ursula BMC Infect Dis Research Article BACKGROUND: Pentraxin-3 (PTX-3) is an acute-phase protein involved in inflammatory and infectious processes. This study assesses its diagnostic and prognostic value in patients with sepsis or septic shock in a medical intensive care unit (ICU). METHODS: The study includes 213 ICU patients with clinical criteria of sepsis and septic shock. 77 donors served as controls. Plasma levels of PTX-3, procalcitonin (PCT) and interleukin-6 were measured on day 1, 3 and 8. RESULTS: PTX-3 correlated with higher lactate levels as well as with APACHE II and SOFA scores (p = 0.0001). PTX-3 levels of patients with sepsis or septic shock were consistently significantly higher than in the control group (p ≤ 0.001). Plasma levels were able to discriminate sepsis and septic shock significantly on day 1, 3 and 8 (range of AUC 0.73–0.92, p = 0.0001). Uniform cut-off levels were defined at ≥5 ng/ml for at least sepsis, ≥9 ng/ml for septic shock (p = 0.0001). CONCLUSION: PTX-3 reveals diagnostic value for sepsis and septic shock during the first week of intensive care treatment, comparable to interleukin-6 according to latest Sepsis-3 definitions. TRIAL REGISTRATION: NCT01535534. Registered 14.02.2012 BioMed Central 2017-08-09 /pmc/articles/PMC5550951/ /pubmed/28793880 http://dx.doi.org/10.1186/s12879-017-2606-3 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Hamed, Sonja
Behnes, Michael
Pauly, Dominic
Lepiorz, Dominic
Barre, Max
Becher, Tobias
Lang, Siegfried
Akin, Ibrahim
Borggrefe, Martin
Bertsch, Thomas
Hoffmann, Ursula
Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
title Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
title_full Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
title_fullStr Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
title_full_unstemmed Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
title_short Diagnostic value of Pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
title_sort diagnostic value of pentraxin-3 in patients with sepsis and septic shock in accordance with latest sepsis-3 definitions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550951/
https://www.ncbi.nlm.nih.gov/pubmed/28793880
http://dx.doi.org/10.1186/s12879-017-2606-3
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