Hydroxychloroquine inhibits CD154 expression in CD4(+) T lymphocytes of systemic lupus erythematosus through NFAT, but not STAT5, signaling

BACKGROUND: Overexpression of membranous CD154 in T lymphocytes has been found previously in systemic lupus erythematosus (SLE). Because hydroxychloroquine (HCQ) has been used frequently in the treatment of lupus, we sought to identify the effects of HCQ on CD154 and a possibly regulatory mechanism....

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Detalles Bibliográficos
Autores principales: Wu, Shu-Fen, Chang, Chia-Bin, Hsu, Jui-Mei, Lu, Ming-Chi, Lai, Ning-Sheng, Li, Chin, Tung, Chien-Hsueh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550984/
https://www.ncbi.nlm.nih.gov/pubmed/28793932
http://dx.doi.org/10.1186/s13075-017-1393-y

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