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Physical shearing imparts biological activity to DNA and ability to transmit itself horizontally across species and kingdom boundaries
BACKGROUND: We have recently reported that cell-free DNA (cfDNA) fragments derived from dying cells that circulate in blood are biologically active molecules and can readily enter into healthy cells to activate DNA damage and apoptotic responses in the recipients. However, DNA is not conventionally...
Autores principales: | Raghuram, Gorantla Venkata, Gupta, Deepika, Subramaniam, Siddharth, Gaikwad, Ashwini, Khare, Naveen Kumar, Nobre, Malcolm, Nair, Naveen Kumar, Mittra, Indraneel |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5550992/ https://www.ncbi.nlm.nih.gov/pubmed/28793862 http://dx.doi.org/10.1186/s12867-017-0098-8 |
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