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The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis

Background: DNA methylation in sputum has been an attractive candidate biomarker for the non-invasive screening and detection of lung cancer. Materials and Methods: Databases including PubMed, Ovid, Cochrane library, Web of Science databases, Chinese Biological Medicine (CBM), Chinese National Knowl...

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Autores principales: Liu, Di, Peng, Hongli, Sun, Qi, Zhao, Zhongyao, Yu, Xinwei, Ge, Siqi, Wang, Hao, Fang, Honghong, Gao, Qing, Liu, Jiaonan, Wu, Lijuan, Song, Manshu, Wang, Youxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551117/
https://www.ncbi.nlm.nih.gov/pubmed/28644424
http://dx.doi.org/10.3390/ijerph14070679
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author Liu, Di
Peng, Hongli
Sun, Qi
Zhao, Zhongyao
Yu, Xinwei
Ge, Siqi
Wang, Hao
Fang, Honghong
Gao, Qing
Liu, Jiaonan
Wu, Lijuan
Song, Manshu
Wang, Youxin
author_facet Liu, Di
Peng, Hongli
Sun, Qi
Zhao, Zhongyao
Yu, Xinwei
Ge, Siqi
Wang, Hao
Fang, Honghong
Gao, Qing
Liu, Jiaonan
Wu, Lijuan
Song, Manshu
Wang, Youxin
author_sort Liu, Di
collection PubMed
description Background: DNA methylation in sputum has been an attractive candidate biomarker for the non-invasive screening and detection of lung cancer. Materials and Methods: Databases including PubMed, Ovid, Cochrane library, Web of Science databases, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang, Vip Databases and Google Scholar were searched to collect the diagnostic trials on aberrant DNA methylation in the screening and detection of lung cancer published until 1 December 2016. Indirect comparison meta-analysis was used to evaluate the diagnostic value of the included candidate genes. Results: The systematic literature search yielded a total of 33 studies including a total of 4801 subjects (2238 patients with lung cancer and 2563 controls) and covering 32 genes. We identified that methylated genes in sputum samples for the early screening and auxiliary detection of lung cancer yielded an overall sensitivity of 0.46 (0.41–0.50) and specificity of 0.83 (0.80–0.86). Combined indirect comparisons identified the superior gene of SOX17 (sensitivity: 0.84, specificity: 0.88), CDO1 (sensitivity: 0.78, specificity: 0.67), ZFP42 (sensitivity: 0.87, specificity: 0.63) and TAC1 (sensitivity: 0.86, specificity: 0.75). Conclusions: The present meta-analysis demonstrates that methylated SOX17, CDO1, ZFP42, TAC1, FAM19A4, FHIT, MGMT, p16, and RASSF1A are potential superior biomarkers for the screening and auxiliary detection of lung cancer.
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spelling pubmed-55511172017-08-11 The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis Liu, Di Peng, Hongli Sun, Qi Zhao, Zhongyao Yu, Xinwei Ge, Siqi Wang, Hao Fang, Honghong Gao, Qing Liu, Jiaonan Wu, Lijuan Song, Manshu Wang, Youxin Int J Environ Res Public Health Review Background: DNA methylation in sputum has been an attractive candidate biomarker for the non-invasive screening and detection of lung cancer. Materials and Methods: Databases including PubMed, Ovid, Cochrane library, Web of Science databases, Chinese Biological Medicine (CBM), Chinese National Knowledge Infrastructure (CNKI), Wanfang, Vip Databases and Google Scholar were searched to collect the diagnostic trials on aberrant DNA methylation in the screening and detection of lung cancer published until 1 December 2016. Indirect comparison meta-analysis was used to evaluate the diagnostic value of the included candidate genes. Results: The systematic literature search yielded a total of 33 studies including a total of 4801 subjects (2238 patients with lung cancer and 2563 controls) and covering 32 genes. We identified that methylated genes in sputum samples for the early screening and auxiliary detection of lung cancer yielded an overall sensitivity of 0.46 (0.41–0.50) and specificity of 0.83 (0.80–0.86). Combined indirect comparisons identified the superior gene of SOX17 (sensitivity: 0.84, specificity: 0.88), CDO1 (sensitivity: 0.78, specificity: 0.67), ZFP42 (sensitivity: 0.87, specificity: 0.63) and TAC1 (sensitivity: 0.86, specificity: 0.75). Conclusions: The present meta-analysis demonstrates that methylated SOX17, CDO1, ZFP42, TAC1, FAM19A4, FHIT, MGMT, p16, and RASSF1A are potential superior biomarkers for the screening and auxiliary detection of lung cancer. MDPI 2017-06-23 2017-07 /pmc/articles/PMC5551117/ /pubmed/28644424 http://dx.doi.org/10.3390/ijerph14070679 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Di
Peng, Hongli
Sun, Qi
Zhao, Zhongyao
Yu, Xinwei
Ge, Siqi
Wang, Hao
Fang, Honghong
Gao, Qing
Liu, Jiaonan
Wu, Lijuan
Song, Manshu
Wang, Youxin
The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis
title The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis
title_full The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis
title_fullStr The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis
title_full_unstemmed The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis
title_short The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis
title_sort indirect efficacy comparison of dna methylation in sputum for early screening and auxiliary detection of lung cancer: a meta-analysis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551117/
https://www.ncbi.nlm.nih.gov/pubmed/28644424
http://dx.doi.org/10.3390/ijerph14070679
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