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Epidural scarring after lumbar disc surgery: Equivalent scarring with/without free autologous fat grafts

BACKGROUND: To limit epidural fibrosis and prevent scar formation/nerve tethering that may contribute to chronic postoperative pain; some surgeons have utilized epidural autologous fat grafts following lumbar microdiscectomy. METHODS: We investigated the correlation between post-microdiscectomy epid...

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Autores principales: Dobran, M., Brancorsini, D., Costanza, M. Della, Liverotti, V., Mancini, F., Nasi, D., Iacoangeli, M., Scerrati, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551283/
https://www.ncbi.nlm.nih.gov/pubmed/28840073
http://dx.doi.org/10.4103/sni.sni_142_17
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author Dobran, M.
Brancorsini, D.
Costanza, M. Della
Liverotti, V.
Mancini, F.
Nasi, D.
Iacoangeli, M.
Scerrati, M.
author_facet Dobran, M.
Brancorsini, D.
Costanza, M. Della
Liverotti, V.
Mancini, F.
Nasi, D.
Iacoangeli, M.
Scerrati, M.
author_sort Dobran, M.
collection PubMed
description BACKGROUND: To limit epidural fibrosis and prevent scar formation/nerve tethering that may contribute to chronic postoperative pain; some surgeons have utilized epidural autologous fat grafts following lumbar microdiscectomy. METHODS: We investigated the correlation between post-microdiscectomy epidural scarring [including select magnetic resonance imaging (MRI) studies] and clinical outcomes in 36 patients operated for symptomatic. MRI documented L4-L5 and L5-S1 disk herniations with (18 patients) and without (18 patient) the application of free fat grafts. In addition, histological evaluation of the original fat grafts was performed in 4 patients requiring additional surgery. RESULTS: We found no clear association between the use of autologous graft fats and the clinical outcomes in this study. CONCLUSION: In this preliminary study involving only 36 patients, the prospective randomized use of free autologous fat grafts did not appear to influence outcomes following microdiscectomy.
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spelling pubmed-55512832017-08-24 Epidural scarring after lumbar disc surgery: Equivalent scarring with/without free autologous fat grafts Dobran, M. Brancorsini, D. Costanza, M. Della Liverotti, V. Mancini, F. Nasi, D. Iacoangeli, M. Scerrati, M. Surg Neurol Int Spine: Original Article BACKGROUND: To limit epidural fibrosis and prevent scar formation/nerve tethering that may contribute to chronic postoperative pain; some surgeons have utilized epidural autologous fat grafts following lumbar microdiscectomy. METHODS: We investigated the correlation between post-microdiscectomy epidural scarring [including select magnetic resonance imaging (MRI) studies] and clinical outcomes in 36 patients operated for symptomatic. MRI documented L4-L5 and L5-S1 disk herniations with (18 patients) and without (18 patient) the application of free fat grafts. In addition, histological evaluation of the original fat grafts was performed in 4 patients requiring additional surgery. RESULTS: We found no clear association between the use of autologous graft fats and the clinical outcomes in this study. CONCLUSION: In this preliminary study involving only 36 patients, the prospective randomized use of free autologous fat grafts did not appear to influence outcomes following microdiscectomy. Medknow Publications & Media Pvt Ltd 2017-08-01 /pmc/articles/PMC5551283/ /pubmed/28840073 http://dx.doi.org/10.4103/sni.sni_142_17 Text en Copyright: © 2017 Surgical Neurology International http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Spine: Original Article
Dobran, M.
Brancorsini, D.
Costanza, M. Della
Liverotti, V.
Mancini, F.
Nasi, D.
Iacoangeli, M.
Scerrati, M.
Epidural scarring after lumbar disc surgery: Equivalent scarring with/without free autologous fat grafts
title Epidural scarring after lumbar disc surgery: Equivalent scarring with/without free autologous fat grafts
title_full Epidural scarring after lumbar disc surgery: Equivalent scarring with/without free autologous fat grafts
title_fullStr Epidural scarring after lumbar disc surgery: Equivalent scarring with/without free autologous fat grafts
title_full_unstemmed Epidural scarring after lumbar disc surgery: Equivalent scarring with/without free autologous fat grafts
title_short Epidural scarring after lumbar disc surgery: Equivalent scarring with/without free autologous fat grafts
title_sort epidural scarring after lumbar disc surgery: equivalent scarring with/without free autologous fat grafts
topic Spine: Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551283/
https://www.ncbi.nlm.nih.gov/pubmed/28840073
http://dx.doi.org/10.4103/sni.sni_142_17
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