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Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis

BACKGROUND AND OBJECTIVE: Some studies suggest that psychological condition and stress can play role in the development of recurrent aphthous stomatitis (RAS). The purpose of this study was to evaluate salivary cortisol changes and psychological conditions in patients with RAS. MATERIALS AND METHODS...

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Autores principales: Rezaei, Fatemeh, Aminian, Maziar, Raygani, Asad Vaisi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551332/
https://www.ncbi.nlm.nih.gov/pubmed/28839413
http://dx.doi.org/10.4103/ccd.ccd_165_17
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author Rezaei, Fatemeh
Aminian, Maziar
Raygani, Asad Vaisi
author_facet Rezaei, Fatemeh
Aminian, Maziar
Raygani, Asad Vaisi
author_sort Rezaei, Fatemeh
collection PubMed
description BACKGROUND AND OBJECTIVE: Some studies suggest that psychological condition and stress can play role in the development of recurrent aphthous stomatitis (RAS). The purpose of this study was to evaluate salivary cortisol changes and psychological conditions in patients with RAS. MATERIALS AND METHODS: Twenty-seven patients (13 males and 14 females, mean age of 32.8 (±10.2) years) with minor RAS and 27 age- and sex-matched controls without RAS participated in this study. The concentration of cortisol (nanomole/L) was measured in samples of unstimulated saliva from patients and controls two times; once during the presence of active lesions and once again when the lesions had healed by immunologic assay. The Hospital Anxiety and Depression Scale was employed to determine psychological condition. Visual analog scale for pain severity was recorded for patients with active lesions episode. Data were analyzed by the SPSS software (version 18.0) using paired and unpaired t-tests and Pearson correlation coefficient. RESULTS: Salivary cortisol level was lower in patients during active lesions (12.4 ± 5.1) and healing (10.5 ± 3.9) episodes compared to the controls (13.1 ± 3.6) (P = 0.583, P = 0.015; respectively). There was no significant difference in salivary cortisol between active lesions and healing episodes (P = 0.943). Anxiety and depression represented no significant differences between active lesions and healing episodes (P > 0.05). Anxiety and depression levels in patients were significantly higher than in controls (P < 0.05). Pain severity in active lesions was not significantly correlated to salivary cortisol level, and anxiety or depression scores (P > 0.05). CONCLUSION: The findings showed that occurrence of RAS was associated with anxiety and depression but not with alterations of salivary cortisol level.
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spelling pubmed-55513322017-08-24 Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis Rezaei, Fatemeh Aminian, Maziar Raygani, Asad Vaisi Contemp Clin Dent Original Article BACKGROUND AND OBJECTIVE: Some studies suggest that psychological condition and stress can play role in the development of recurrent aphthous stomatitis (RAS). The purpose of this study was to evaluate salivary cortisol changes and psychological conditions in patients with RAS. MATERIALS AND METHODS: Twenty-seven patients (13 males and 14 females, mean age of 32.8 (±10.2) years) with minor RAS and 27 age- and sex-matched controls without RAS participated in this study. The concentration of cortisol (nanomole/L) was measured in samples of unstimulated saliva from patients and controls two times; once during the presence of active lesions and once again when the lesions had healed by immunologic assay. The Hospital Anxiety and Depression Scale was employed to determine psychological condition. Visual analog scale for pain severity was recorded for patients with active lesions episode. Data were analyzed by the SPSS software (version 18.0) using paired and unpaired t-tests and Pearson correlation coefficient. RESULTS: Salivary cortisol level was lower in patients during active lesions (12.4 ± 5.1) and healing (10.5 ± 3.9) episodes compared to the controls (13.1 ± 3.6) (P = 0.583, P = 0.015; respectively). There was no significant difference in salivary cortisol between active lesions and healing episodes (P = 0.943). Anxiety and depression represented no significant differences between active lesions and healing episodes (P > 0.05). Anxiety and depression levels in patients were significantly higher than in controls (P < 0.05). Pain severity in active lesions was not significantly correlated to salivary cortisol level, and anxiety or depression scores (P > 0.05). CONCLUSION: The findings showed that occurrence of RAS was associated with anxiety and depression but not with alterations of salivary cortisol level. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5551332/ /pubmed/28839413 http://dx.doi.org/10.4103/ccd.ccd_165_17 Text en Copyright: © 2017 Contemporary Clinical Dentistry http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Rezaei, Fatemeh
Aminian, Maziar
Raygani, Asad Vaisi
Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis
title Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis
title_full Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis
title_fullStr Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis
title_full_unstemmed Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis
title_short Evaluation of Salivary Cortisol Changes and Psychological Profiles in Patients with Recurrent Aphthous Stomatitis
title_sort evaluation of salivary cortisol changes and psychological profiles in patients with recurrent aphthous stomatitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551332/
https://www.ncbi.nlm.nih.gov/pubmed/28839413
http://dx.doi.org/10.4103/ccd.ccd_165_17
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