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The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment

Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called...

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Detalles Bibliográficos
Autores principales: Varas-Godoy, Manuel, Rice, Gregory, Illanes, Sebastián E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551518/
https://www.ncbi.nlm.nih.gov/pubmed/28819364
http://dx.doi.org/10.1155/2017/5263974
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author Varas-Godoy, Manuel
Rice, Gregory
Illanes, Sebastián E.
author_facet Varas-Godoy, Manuel
Rice, Gregory
Illanes, Sebastián E.
author_sort Varas-Godoy, Manuel
collection PubMed
description Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity. These cells reside in a niche that maintains the principal properties of CSCs. These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche. In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer.
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spelling pubmed-55515182017-08-17 The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment Varas-Godoy, Manuel Rice, Gregory Illanes, Sebastián E. Stem Cells Int Review Article Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity. These cells reside in a niche that maintains the principal properties of CSCs. These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche. In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer. Hindawi 2017 2017-07-27 /pmc/articles/PMC5551518/ /pubmed/28819364 http://dx.doi.org/10.1155/2017/5263974 Text en Copyright © 2017 Manuel Varas-Godoy et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Varas-Godoy, Manuel
Rice, Gregory
Illanes, Sebastián E.
The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
title The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
title_full The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
title_fullStr The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
title_full_unstemmed The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
title_short The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
title_sort crosstalk between ovarian cancer stem cell niche and the tumor microenvironment
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551518/
https://www.ncbi.nlm.nih.gov/pubmed/28819364
http://dx.doi.org/10.1155/2017/5263974
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