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The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551518/ https://www.ncbi.nlm.nih.gov/pubmed/28819364 http://dx.doi.org/10.1155/2017/5263974 |
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author | Varas-Godoy, Manuel Rice, Gregory Illanes, Sebastián E. |
author_facet | Varas-Godoy, Manuel Rice, Gregory Illanes, Sebastián E. |
author_sort | Varas-Godoy, Manuel |
collection | PubMed |
description | Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity. These cells reside in a niche that maintains the principal properties of CSCs. These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche. In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer. |
format | Online Article Text |
id | pubmed-5551518 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-55515182017-08-17 The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment Varas-Godoy, Manuel Rice, Gregory Illanes, Sebastián E. Stem Cells Int Review Article Ovarian cancer is one of the most important causes of cancer-related death among women in the world. Despite advances in ovarian cancer treatment, 70–80% of women who initially respond to therapy eventually relapse and die. There is evidence that a small population of cells within the tumors called cancer stem cells (CSCs) could be responsible for treatment failure due to their enhanced chemoresistance and tumorigenicity. These cells reside in a niche that maintains the principal properties of CSCs. These properties are associated with the capacity of CSCs to interact with different cells of the tumor microenvironment including mesenchymal stem cells, endothelial cells, immune cells, and fibroblasts, promoting cancer progression. This interaction can be mediated by cytokines, growth factors, lipids, and/or extracellular vesicles released in the CSC niche. In this review, we will discuss how the interaction between ovarian CSCs and the tumor microenvironment can contribute to the maintenance of the CSC niche and consequently to tumor progression in ovarian cancer. Hindawi 2017 2017-07-27 /pmc/articles/PMC5551518/ /pubmed/28819364 http://dx.doi.org/10.1155/2017/5263974 Text en Copyright © 2017 Manuel Varas-Godoy et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Varas-Godoy, Manuel Rice, Gregory Illanes, Sebastián E. The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
title | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
title_full | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
title_fullStr | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
title_full_unstemmed | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
title_short | The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment |
title_sort | crosstalk between ovarian cancer stem cell niche and the tumor microenvironment |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551518/ https://www.ncbi.nlm.nih.gov/pubmed/28819364 http://dx.doi.org/10.1155/2017/5263974 |
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