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Therapeutic antibody targeting of Notch3 signaling prevents mural cell loss in CADASIL

Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a neurological syndrome characterized by small vessel disease (SVD), stroke, and vascular cognitive impairment and dementia caused by mutations in NOTCH3. No therapies are available for this condi...

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Detalles Bibliográficos
Autores principales:	Machuca-Parra, Arturo I., Bigger-Allen, Alexander A., Sanchez, Angie V., Boutabla, Anissa, Cardona-Vélez, Jonathan, Amarnani, Dhanesh, Saint-Geniez, Magali, Siebel, Christian W., Kim, Leo A., D’Amore, Patricia A., Arboleda-Velasquez, Joseph F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551569/ https://www.ncbi.nlm.nih.gov/pubmed/28698285 http://dx.doi.org/10.1084/jem.20161715

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