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The islet-resident macrophage is in an inflammatory state and senses microbial products in blood

We examined the transcriptional profiles of macrophages that reside in the islets of Langerhans of 3-wk-old non-obese diabetic (NOD), NOD.Rag1(−/−), and B6.g7 mice. Islet macrophages expressed an activation signature with high expression of Tnf, Il1b, and MHC-II at both the transcript and protein le...

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Detalles Bibliográficos
Autores principales:	Ferris, Stephen T., Zakharov, Pavel N., Wan, Xiaoxiao, Calderon, Boris, Artyomov, Maxim N., Unanue, Emil R., Carrero, Javier A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551574/ https://www.ncbi.nlm.nih.gov/pubmed/28630088 http://dx.doi.org/10.1084/jem.20170074

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