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Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation
Specialized assembly factors facilitate the formation of many macromolecular complexes in vivo. The formation of Sm core structures of spliceosomal U-rich small nuclear ribonucleoprotein particles (UsnRNPs) requires assembly factors united in protein arginine methyltransferase 5 (PRMT5) and survival...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551706/ https://www.ncbi.nlm.nih.gov/pubmed/28637748 http://dx.doi.org/10.1083/jcb.201611108 |