De novo telomere addition at chromosome breaks: Dangerous Liaisons

Telomerase counteracts the loss of terminal DNA sequences from chromosome ends; however, it may erroneously add telomeric repeats to DNA double-strand breaks. In this issue, Ouenzar et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610071) uncover cell cycle–dependent sequestration of the t...

Descripción completa

Detalles Bibliográficos
Autores principales: Churikov, Dmitri, Géli, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551718/
https://www.ncbi.nlm.nih.gov/pubmed/28710328
http://dx.doi.org/10.1083/jcb.201705156
Descripción
Sumario:Telomerase counteracts the loss of terminal DNA sequences from chromosome ends; however, it may erroneously add telomeric repeats to DNA double-strand breaks. In this issue, Ouenzar et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201610071) uncover cell cycle–dependent sequestration of the telomerase RNA in nucleoli, a process that excludes telomerase from DNA repair sites.

Ejemplares similares