More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines

Synaptic activity reshapes the morphology of dendritic spines via regulating F-actin arborization. In this issue, Lei et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612042) reports a novel, G-actin–dependent regulation of actin polymerization within spine heads. They show that actin mono...

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Detalles Bibliográficos
Autor principal: Schlett, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551720/
https://www.ncbi.nlm.nih.gov/pubmed/28701424
http://dx.doi.org/10.1083/jcb.201705216
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author Schlett, Katalin
author_facet Schlett, Katalin
author_sort Schlett, Katalin
collection PubMed
description Synaptic activity reshapes the morphology of dendritic spines via regulating F-actin arborization. In this issue, Lei et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612042) reports a novel, G-actin–dependent regulation of actin polymerization within spine heads. They show that actin monomer levels are elevated in spines upon activity, with G-actin immobilized by the local enrichment of phosphatidylinositol (3,4,5)-triphosphate (PIP(3)) within the spine plasma membrane.
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spelling pubmed-55517202018-02-07 More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines Schlett, Katalin J Cell Biol Commentary Synaptic activity reshapes the morphology of dendritic spines via regulating F-actin arborization. In this issue, Lei et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612042) reports a novel, G-actin–dependent regulation of actin polymerization within spine heads. They show that actin monomer levels are elevated in spines upon activity, with G-actin immobilized by the local enrichment of phosphatidylinositol (3,4,5)-triphosphate (PIP(3)) within the spine plasma membrane. The Rockefeller University Press 2017-08-07 /pmc/articles/PMC5551720/ /pubmed/28701424 http://dx.doi.org/10.1083/jcb.201705216 Text en © 2017 Schlett http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Schlett, Katalin
More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines
title More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines
title_full More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines
title_fullStr More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines
title_full_unstemmed More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines
title_short More than a mere supply of monomers: G-Actin pools regulate actin dynamics in dendritic spines
title_sort more than a mere supply of monomers: g-actin pools regulate actin dynamics in dendritic spines
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551720/
https://www.ncbi.nlm.nih.gov/pubmed/28701424
http://dx.doi.org/10.1083/jcb.201705216
work_keys_str_mv AT schlettkatalin morethanameresupplyofmonomersgactinpoolsregulateactindynamicsindendriticspines

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