Strength in numbers: Phosphofructokinase polymerization prevails in the liver

Numerous metabolic enzymes assemble into filamentous structures, which are thought to serve additional regulatory functions. In this issue, Webb et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701084) show that the liver-specific isoform of phosphofructokinase-1 forms filaments in vitro a...

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Detalles Bibliográficos
Autores principales: Zaganjor, Elma, Spinelli, Jessica B., Haigis, Marcia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551721/
https://www.ncbi.nlm.nih.gov/pubmed/28716843
http://dx.doi.org/10.1083/jcb.201706005
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author Zaganjor, Elma
Spinelli, Jessica B.
Haigis, Marcia C.
author_facet Zaganjor, Elma
Spinelli, Jessica B.
Haigis, Marcia C.
author_sort Zaganjor, Elma
collection PubMed
description Numerous metabolic enzymes assemble into filamentous structures, which are thought to serve additional regulatory functions. In this issue, Webb et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701084) show that the liver-specific isoform of phosphofructokinase-1 forms filaments in vitro and localizes as puncta in cells along the plasma membrane. This suggests spatial organization of glycolysis in higher organisms.
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spelling pubmed-55517212018-02-07 Strength in numbers: Phosphofructokinase polymerization prevails in the liver Zaganjor, Elma Spinelli, Jessica B. Haigis, Marcia C. J Cell Biol Commentary Numerous metabolic enzymes assemble into filamentous structures, which are thought to serve additional regulatory functions. In this issue, Webb et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701084) show that the liver-specific isoform of phosphofructokinase-1 forms filaments in vitro and localizes as puncta in cells along the plasma membrane. This suggests spatial organization of glycolysis in higher organisms. The Rockefeller University Press 2017-08-07 /pmc/articles/PMC5551721/ /pubmed/28716843 http://dx.doi.org/10.1083/jcb.201706005 Text en © 2017 Zaganjor et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Zaganjor, Elma
Spinelli, Jessica B.
Haigis, Marcia C.
Strength in numbers: Phosphofructokinase polymerization prevails in the liver
title Strength in numbers: Phosphofructokinase polymerization prevails in the liver
title_full Strength in numbers: Phosphofructokinase polymerization prevails in the liver
title_fullStr Strength in numbers: Phosphofructokinase polymerization prevails in the liver
title_full_unstemmed Strength in numbers: Phosphofructokinase polymerization prevails in the liver
title_short Strength in numbers: Phosphofructokinase polymerization prevails in the liver
title_sort strength in numbers: phosphofructokinase polymerization prevails in the liver
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551721/
https://www.ncbi.nlm.nih.gov/pubmed/28716843
http://dx.doi.org/10.1083/jcb.201706005
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