RNA gets in phase

Several neurological disorders are linked to tandem nucleotide repeat expansion in the mutated gene. Jain and Vale (2017. Nature. https://doi.org/10.1038/nature22386) show that, above a pathological threshold repeat number, base pairing interactions drive phase separation of RNA into membrane-less g...

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Detalles Bibliográficos
Autores principales: Saha, Shambaditya, Hyman, Anthony A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551722/
https://www.ncbi.nlm.nih.gov/pubmed/28667121
http://dx.doi.org/10.1083/jcb.201706034
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author Saha, Shambaditya
Hyman, Anthony A.
author_facet Saha, Shambaditya
Hyman, Anthony A.
author_sort Saha, Shambaditya
collection PubMed
description Several neurological disorders are linked to tandem nucleotide repeat expansion in the mutated gene. Jain and Vale (2017. Nature. https://doi.org/10.1038/nature22386) show that, above a pathological threshold repeat number, base pairing interactions drive phase separation of RNA into membrane-less gels, suggesting that RNA can scaffold the assembly of phase-separated compartments that sequester proteins/RNAs causing toxicity.
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spelling pubmed-55517222018-02-07 RNA gets in phase Saha, Shambaditya Hyman, Anthony A. J Cell Biol Commentary Several neurological disorders are linked to tandem nucleotide repeat expansion in the mutated gene. Jain and Vale (2017. Nature. https://doi.org/10.1038/nature22386) show that, above a pathological threshold repeat number, base pairing interactions drive phase separation of RNA into membrane-less gels, suggesting that RNA can scaffold the assembly of phase-separated compartments that sequester proteins/RNAs causing toxicity. The Rockefeller University Press 2017-08-07 /pmc/articles/PMC5551722/ /pubmed/28667121 http://dx.doi.org/10.1083/jcb.201706034 Text en © 2017 Saha and Hyman http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Saha, Shambaditya
Hyman, Anthony A.
RNA gets in phase
title RNA gets in phase
title_full RNA gets in phase
title_fullStr RNA gets in phase
title_full_unstemmed RNA gets in phase
title_short RNA gets in phase
title_sort rna gets in phase
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551722/
https://www.ncbi.nlm.nih.gov/pubmed/28667121
http://dx.doi.org/10.1083/jcb.201706034
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