Lysosomes convene to keep the synapse clean

In neurons, lysosomes regulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor levels at the plasma membrane, although their presence at distal dendrites is controversial. In this issue, Goo et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201704068) show for the first time that...

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Detalles Bibliográficos
Autor principal: Kononenko, Natalia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551723/
https://www.ncbi.nlm.nih.gov/pubmed/28724526
http://dx.doi.org/10.1083/jcb.201707070
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author Kononenko, Natalia L.
author_facet Kononenko, Natalia L.
author_sort Kononenko, Natalia L.
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description In neurons, lysosomes regulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor levels at the plasma membrane, although their presence at distal dendrites is controversial. In this issue, Goo et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201704068) show for the first time that neuronal activity positions lysosomes at the dendritic spines to facilitate synaptic remodeling through local protein degradation.
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spelling pubmed-55517232018-02-07 Lysosomes convene to keep the synapse clean Kononenko, Natalia L. J Cell Biol Commentary In neurons, lysosomes regulate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor levels at the plasma membrane, although their presence at distal dendrites is controversial. In this issue, Goo et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201704068) show for the first time that neuronal activity positions lysosomes at the dendritic spines to facilitate synaptic remodeling through local protein degradation. The Rockefeller University Press 2017-08-07 /pmc/articles/PMC5551723/ /pubmed/28724526 http://dx.doi.org/10.1083/jcb.201707070 Text en © 2017 Kononenko http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
Kononenko, Natalia L.
Lysosomes convene to keep the synapse clean
title Lysosomes convene to keep the synapse clean
title_full Lysosomes convene to keep the synapse clean
title_fullStr Lysosomes convene to keep the synapse clean
title_full_unstemmed Lysosomes convene to keep the synapse clean
title_short Lysosomes convene to keep the synapse clean
title_sort lysosomes convene to keep the synapse clean
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551723/
https://www.ncbi.nlm.nih.gov/pubmed/28724526
http://dx.doi.org/10.1083/jcb.201707070
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