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Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications

Despite their good biocompatibility and adequate mechanical behavior, the main limitation of Mg alloys might be their high degradation rates in a physiological environment. In this study, a novel Mg-based alloy exhibiting an elastic modulus E = 42 GPa, Mg-1Ca-0.2Mn-0.6Zr, was synthesized and thermo-...

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Autores principales: Neacsu, Patricia, Staras, Adela Ioana, Voicu, Stefan Ioan, Ionascu, Iuliana, Soare, Teodoru, Uzun, Seralp, Cojocaru, Vasile Danut, Pandele, Andreea Madalina, Croitoru, Sorin Mihai, Miculescu, Florin, Cotrut, Cosmin Mihai, Dan, Ioan, Cimpean, Anisoara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551729/
https://www.ncbi.nlm.nih.gov/pubmed/28773046
http://dx.doi.org/10.3390/ma10070686
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author Neacsu, Patricia
Staras, Adela Ioana
Voicu, Stefan Ioan
Ionascu, Iuliana
Soare, Teodoru
Uzun, Seralp
Cojocaru, Vasile Danut
Pandele, Andreea Madalina
Croitoru, Sorin Mihai
Miculescu, Florin
Cotrut, Cosmin Mihai
Dan, Ioan
Cimpean, Anisoara
author_facet Neacsu, Patricia
Staras, Adela Ioana
Voicu, Stefan Ioan
Ionascu, Iuliana
Soare, Teodoru
Uzun, Seralp
Cojocaru, Vasile Danut
Pandele, Andreea Madalina
Croitoru, Sorin Mihai
Miculescu, Florin
Cotrut, Cosmin Mihai
Dan, Ioan
Cimpean, Anisoara
author_sort Neacsu, Patricia
collection PubMed
description Despite their good biocompatibility and adequate mechanical behavior, the main limitation of Mg alloys might be their high degradation rates in a physiological environment. In this study, a novel Mg-based alloy exhibiting an elastic modulus E = 42 GPa, Mg-1Ca-0.2Mn-0.6Zr, was synthesized and thermo-mechanically processed. In order to improve its performance as a temporary bone implant, a coating based on cellulose acetate (CA) was realized by using the dipping method. The formation of the polymer coating was demonstrated by FT-IR, XPS, SEM and corrosion behavior comparative analyses of both uncoated and CA-coated alloys. The potentiodynamic polarization test revealed that the CA coating significantly improved the corrosion resistance of the Mg alloy. Using a series of in vitro and in vivo experiments, the biocompatibility of both groups of biomaterials was assessed. In vitro experiments demonstrated that the media containing their extracts showed good cytocompatibility on MC3T3-E1 pre-osteoblasts in terms of cell adhesion and spreading, viability, proliferation and osteogenic differentiation. In vivo studies conducted in rats revealed that the intramedullary coated implant for fixation of femur fracture was more efficient in inducing bone regeneration than the uncoated one. In this manner, the present study suggests that the CA-coated Mg-based alloy holds promise for orthopedic aplications.
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spelling pubmed-55517292017-08-11 Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications Neacsu, Patricia Staras, Adela Ioana Voicu, Stefan Ioan Ionascu, Iuliana Soare, Teodoru Uzun, Seralp Cojocaru, Vasile Danut Pandele, Andreea Madalina Croitoru, Sorin Mihai Miculescu, Florin Cotrut, Cosmin Mihai Dan, Ioan Cimpean, Anisoara Materials (Basel) Article Despite their good biocompatibility and adequate mechanical behavior, the main limitation of Mg alloys might be their high degradation rates in a physiological environment. In this study, a novel Mg-based alloy exhibiting an elastic modulus E = 42 GPa, Mg-1Ca-0.2Mn-0.6Zr, was synthesized and thermo-mechanically processed. In order to improve its performance as a temporary bone implant, a coating based on cellulose acetate (CA) was realized by using the dipping method. The formation of the polymer coating was demonstrated by FT-IR, XPS, SEM and corrosion behavior comparative analyses of both uncoated and CA-coated alloys. The potentiodynamic polarization test revealed that the CA coating significantly improved the corrosion resistance of the Mg alloy. Using a series of in vitro and in vivo experiments, the biocompatibility of both groups of biomaterials was assessed. In vitro experiments demonstrated that the media containing their extracts showed good cytocompatibility on MC3T3-E1 pre-osteoblasts in terms of cell adhesion and spreading, viability, proliferation and osteogenic differentiation. In vivo studies conducted in rats revealed that the intramedullary coated implant for fixation of femur fracture was more efficient in inducing bone regeneration than the uncoated one. In this manner, the present study suggests that the CA-coated Mg-based alloy holds promise for orthopedic aplications. MDPI 2017-06-22 /pmc/articles/PMC5551729/ /pubmed/28773046 http://dx.doi.org/10.3390/ma10070686 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Neacsu, Patricia
Staras, Adela Ioana
Voicu, Stefan Ioan
Ionascu, Iuliana
Soare, Teodoru
Uzun, Seralp
Cojocaru, Vasile Danut
Pandele, Andreea Madalina
Croitoru, Sorin Mihai
Miculescu, Florin
Cotrut, Cosmin Mihai
Dan, Ioan
Cimpean, Anisoara
Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications
title Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications
title_full Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications
title_fullStr Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications
title_full_unstemmed Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications
title_short Characterization and In Vitro and In Vivo Assessment of a Novel Cellulose Acetate-Coated Mg-Based Alloy for Orthopedic Applications
title_sort characterization and in vitro and in vivo assessment of a novel cellulose acetate-coated mg-based alloy for orthopedic applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551729/
https://www.ncbi.nlm.nih.gov/pubmed/28773046
http://dx.doi.org/10.3390/ma10070686
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