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Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas

Type 1 diabetes (T1D) has been associated with both genetic and environmental factors. Increasing incidence of T1D worldwide is prompting researchers to adopt different approaches to explain the biology of T1D, beyond the presence and activity of autoreactive lymphocytes. In this review, we propose...

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Autores principales: Jean-Baptiste, Virginie S.E., Xia, Chang-Qing, Clare-Salzler, Michael J., Horwitz, Marc S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552106/
https://www.ncbi.nlm.nih.gov/pubmed/28663145
http://dx.doi.org/10.1016/j.ebiom.2017.06.014
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author Jean-Baptiste, Virginie S.E.
Xia, Chang-Qing
Clare-Salzler, Michael J.
Horwitz, Marc S.
author_facet Jean-Baptiste, Virginie S.E.
Xia, Chang-Qing
Clare-Salzler, Michael J.
Horwitz, Marc S.
author_sort Jean-Baptiste, Virginie S.E.
collection PubMed
description Type 1 diabetes (T1D) has been associated with both genetic and environmental factors. Increasing incidence of T1D worldwide is prompting researchers to adopt different approaches to explain the biology of T1D, beyond the presence and activity of autoreactive lymphocytes. In this review, we propose inflammatory pathways as triggers for T1D. Within the scope of those inflammatory pathways and in understanding the pathogenesis of disease, we suggest that viruses, in particular Coxsackieviruses, act by causing a type 1 interferonopathy within the pancreas and the microenvironment of the islet. As such, this connection and common thread represents an exciting platform for the development of new diagnostic, treatment and/or prevention options.
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spelling pubmed-55521062017-08-22 Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas Jean-Baptiste, Virginie S.E. Xia, Chang-Qing Clare-Salzler, Michael J. Horwitz, Marc S. EBioMedicine Review Type 1 diabetes (T1D) has been associated with both genetic and environmental factors. Increasing incidence of T1D worldwide is prompting researchers to adopt different approaches to explain the biology of T1D, beyond the presence and activity of autoreactive lymphocytes. In this review, we propose inflammatory pathways as triggers for T1D. Within the scope of those inflammatory pathways and in understanding the pathogenesis of disease, we suggest that viruses, in particular Coxsackieviruses, act by causing a type 1 interferonopathy within the pancreas and the microenvironment of the islet. As such, this connection and common thread represents an exciting platform for the development of new diagnostic, treatment and/or prevention options. Elsevier 2017-06-21 /pmc/articles/PMC5552106/ /pubmed/28663145 http://dx.doi.org/10.1016/j.ebiom.2017.06.014 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Jean-Baptiste, Virginie S.E.
Xia, Chang-Qing
Clare-Salzler, Michael J.
Horwitz, Marc S.
Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas
title Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas
title_full Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas
title_fullStr Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas
title_full_unstemmed Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas
title_short Type 1 Diabetes and Type 1 Interferonopathies: Localization of a Type 1 Common Thread of Virus Infection in the Pancreas
title_sort type 1 diabetes and type 1 interferonopathies: localization of a type 1 common thread of virus infection in the pancreas
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552106/
https://www.ncbi.nlm.nih.gov/pubmed/28663145
http://dx.doi.org/10.1016/j.ebiom.2017.06.014
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