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A deterministic model for one-dimensional excluded flow with local interactions
Natural phenomena frequently involve a very large number of interacting molecules moving in confined regions of space. Cellular transport by motor proteins is an example of such collective behavior. We derive a deterministic compartmental model for the unidirectional flow of particles along a one-di...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552133/ https://www.ncbi.nlm.nih.gov/pubmed/28796838 http://dx.doi.org/10.1371/journal.pone.0182074 |
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author | Zarai, Yoram Margaliot, Michael Kolomeisky, Anatoly B. |
author_facet | Zarai, Yoram Margaliot, Michael Kolomeisky, Anatoly B. |
author_sort | Zarai, Yoram |
collection | PubMed |
description | Natural phenomena frequently involve a very large number of interacting molecules moving in confined regions of space. Cellular transport by motor proteins is an example of such collective behavior. We derive a deterministic compartmental model for the unidirectional flow of particles along a one-dimensional lattice of sites with nearest-neighbor interactions between the particles. The flow between consecutive sites is governed by a “soft” simple exclusion principle and by attracting or repelling forces between neighboring particles. Using tools from contraction theory, we prove that the model admits a unique steady-state and that every trajectory converges to this steady-state. Analysis and simulations of the effect of the attracting and repelling forces on this steady-state highlight the crucial role that these forces may play in increasing the steady-state flow, and reveal that this increase stems from the alleviation of traffic jams along the lattice. Our theoretical analysis clarifies microscopic aspects of complex multi-particle dynamic processes. |
format | Online Article Text |
id | pubmed-5552133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-55521332017-08-25 A deterministic model for one-dimensional excluded flow with local interactions Zarai, Yoram Margaliot, Michael Kolomeisky, Anatoly B. PLoS One Research Article Natural phenomena frequently involve a very large number of interacting molecules moving in confined regions of space. Cellular transport by motor proteins is an example of such collective behavior. We derive a deterministic compartmental model for the unidirectional flow of particles along a one-dimensional lattice of sites with nearest-neighbor interactions between the particles. The flow between consecutive sites is governed by a “soft” simple exclusion principle and by attracting or repelling forces between neighboring particles. Using tools from contraction theory, we prove that the model admits a unique steady-state and that every trajectory converges to this steady-state. Analysis and simulations of the effect of the attracting and repelling forces on this steady-state highlight the crucial role that these forces may play in increasing the steady-state flow, and reveal that this increase stems from the alleviation of traffic jams along the lattice. Our theoretical analysis clarifies microscopic aspects of complex multi-particle dynamic processes. Public Library of Science 2017-08-10 /pmc/articles/PMC5552133/ /pubmed/28796838 http://dx.doi.org/10.1371/journal.pone.0182074 Text en © 2017 Zarai et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zarai, Yoram Margaliot, Michael Kolomeisky, Anatoly B. A deterministic model for one-dimensional excluded flow with local interactions |
title | A deterministic model for one-dimensional excluded flow with local interactions |
title_full | A deterministic model for one-dimensional excluded flow with local interactions |
title_fullStr | A deterministic model for one-dimensional excluded flow with local interactions |
title_full_unstemmed | A deterministic model for one-dimensional excluded flow with local interactions |
title_short | A deterministic model for one-dimensional excluded flow with local interactions |
title_sort | deterministic model for one-dimensional excluded flow with local interactions |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552133/ https://www.ncbi.nlm.nih.gov/pubmed/28796838 http://dx.doi.org/10.1371/journal.pone.0182074 |
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