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A deterministic model for one-dimensional excluded flow with local interactions

Natural phenomena frequently involve a very large number of interacting molecules moving in confined regions of space. Cellular transport by motor proteins is an example of such collective behavior. We derive a deterministic compartmental model for the unidirectional flow of particles along a one-di...

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Detalles Bibliográficos
Autores principales: Zarai, Yoram, Margaliot, Michael, Kolomeisky, Anatoly B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552133/
https://www.ncbi.nlm.nih.gov/pubmed/28796838
http://dx.doi.org/10.1371/journal.pone.0182074
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author Zarai, Yoram
Margaliot, Michael
Kolomeisky, Anatoly B.
author_facet Zarai, Yoram
Margaliot, Michael
Kolomeisky, Anatoly B.
author_sort Zarai, Yoram
collection PubMed
description Natural phenomena frequently involve a very large number of interacting molecules moving in confined regions of space. Cellular transport by motor proteins is an example of such collective behavior. We derive a deterministic compartmental model for the unidirectional flow of particles along a one-dimensional lattice of sites with nearest-neighbor interactions between the particles. The flow between consecutive sites is governed by a “soft” simple exclusion principle and by attracting or repelling forces between neighboring particles. Using tools from contraction theory, we prove that the model admits a unique steady-state and that every trajectory converges to this steady-state. Analysis and simulations of the effect of the attracting and repelling forces on this steady-state highlight the crucial role that these forces may play in increasing the steady-state flow, and reveal that this increase stems from the alleviation of traffic jams along the lattice. Our theoretical analysis clarifies microscopic aspects of complex multi-particle dynamic processes.
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spelling pubmed-55521332017-08-25 A deterministic model for one-dimensional excluded flow with local interactions Zarai, Yoram Margaliot, Michael Kolomeisky, Anatoly B. PLoS One Research Article Natural phenomena frequently involve a very large number of interacting molecules moving in confined regions of space. Cellular transport by motor proteins is an example of such collective behavior. We derive a deterministic compartmental model for the unidirectional flow of particles along a one-dimensional lattice of sites with nearest-neighbor interactions between the particles. The flow between consecutive sites is governed by a “soft” simple exclusion principle and by attracting or repelling forces between neighboring particles. Using tools from contraction theory, we prove that the model admits a unique steady-state and that every trajectory converges to this steady-state. Analysis and simulations of the effect of the attracting and repelling forces on this steady-state highlight the crucial role that these forces may play in increasing the steady-state flow, and reveal that this increase stems from the alleviation of traffic jams along the lattice. Our theoretical analysis clarifies microscopic aspects of complex multi-particle dynamic processes. Public Library of Science 2017-08-10 /pmc/articles/PMC5552133/ /pubmed/28796838 http://dx.doi.org/10.1371/journal.pone.0182074 Text en © 2017 Zarai et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zarai, Yoram
Margaliot, Michael
Kolomeisky, Anatoly B.
A deterministic model for one-dimensional excluded flow with local interactions
title A deterministic model for one-dimensional excluded flow with local interactions
title_full A deterministic model for one-dimensional excluded flow with local interactions
title_fullStr A deterministic model for one-dimensional excluded flow with local interactions
title_full_unstemmed A deterministic model for one-dimensional excluded flow with local interactions
title_short A deterministic model for one-dimensional excluded flow with local interactions
title_sort deterministic model for one-dimensional excluded flow with local interactions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552133/
https://www.ncbi.nlm.nih.gov/pubmed/28796838
http://dx.doi.org/10.1371/journal.pone.0182074
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