Toxicological and bio-distribution profile of a GM-CSF-expressing, double-targeted, chimeric oncolytic adenovirus ONCOS-102 – Support for clinical studies on advanced cancer treatment

The purpose of this work was to carry out preclinical toxicity and bio-distribution studies required for regulatory approval of a clinical trial application for Phase I clinical studies of ONCOS-102 (Ad5/3-D24-GM-CSF) for therapy of advanced cancers (NCT01598129). The study design, route of administ...

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Detalles Bibliográficos
Autores principales: Kuryk, Lukasz, Vassilev, Lotta, Ranki, Tuuli, Hemminki, Akseli, Karioja-Kallio, Aila, Levälampi, Onerva, Vuolanto, Antti, Cerullo, Vincenzo, Pesonen, Sari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552138/
https://www.ncbi.nlm.nih.gov/pubmed/28796812
http://dx.doi.org/10.1371/journal.pone.0182715

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