Methods to investigate the structure and connectivity of the nervous system

Understanding the computations that take place in neural circuits requires identifying how neurons in those circuits are connected to one another. In addition, recent research indicates that aberrant neuronal wiring may be the cause of several neurodevelopmental disorders, further emphasizing the im...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Donghyung, Huang, Ting-Hao, De La Cruz, Aubrie, Callejas, Antuca, Lois, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552278/
https://www.ncbi.nlm.nih.gov/pubmed/28277925
http://dx.doi.org/10.1080/19336934.2017.1295189
_version_ 1783256444709109760
author Lee, Donghyung
Huang, Ting-Hao
De La Cruz, Aubrie
Callejas, Antuca
Lois, Carlos
author_facet Lee, Donghyung
Huang, Ting-Hao
De La Cruz, Aubrie
Callejas, Antuca
Lois, Carlos
author_sort Lee, Donghyung
collection PubMed
description Understanding the computations that take place in neural circuits requires identifying how neurons in those circuits are connected to one another. In addition, recent research indicates that aberrant neuronal wiring may be the cause of several neurodevelopmental disorders, further emphasizing the importance of identifying the wiring diagrams of brain circuits. To address this issue, several new approaches have been recently developed. In this review, we describe several methods that are currently available to investigate the structure and connectivity of the brain, and discuss their strengths and limitations.
format Online
Article
Text
id pubmed-5552278
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-55522782017-08-16 Methods to investigate the structure and connectivity of the nervous system Lee, Donghyung Huang, Ting-Hao De La Cruz, Aubrie Callejas, Antuca Lois, Carlos Fly (Austin) Review Understanding the computations that take place in neural circuits requires identifying how neurons in those circuits are connected to one another. In addition, recent research indicates that aberrant neuronal wiring may be the cause of several neurodevelopmental disorders, further emphasizing the importance of identifying the wiring diagrams of brain circuits. To address this issue, several new approaches have been recently developed. In this review, we describe several methods that are currently available to investigate the structure and connectivity of the brain, and discuss their strengths and limitations. Taylor & Francis 2017-02-16 /pmc/articles/PMC5552278/ /pubmed/28277925 http://dx.doi.org/10.1080/19336934.2017.1295189 Text en © 2017 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Review
Lee, Donghyung
Huang, Ting-Hao
De La Cruz, Aubrie
Callejas, Antuca
Lois, Carlos
Methods to investigate the structure and connectivity of the nervous system
title Methods to investigate the structure and connectivity of the nervous system
title_full Methods to investigate the structure and connectivity of the nervous system
title_fullStr Methods to investigate the structure and connectivity of the nervous system
title_full_unstemmed Methods to investigate the structure and connectivity of the nervous system
title_short Methods to investigate the structure and connectivity of the nervous system
title_sort methods to investigate the structure and connectivity of the nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552278/
https://www.ncbi.nlm.nih.gov/pubmed/28277925
http://dx.doi.org/10.1080/19336934.2017.1295189
work_keys_str_mv AT leedonghyung methodstoinvestigatethestructureandconnectivityofthenervoussystem
AT huangtinghao methodstoinvestigatethestructureandconnectivityofthenervoussystem
AT delacruzaubrie methodstoinvestigatethestructureandconnectivityofthenervoussystem
AT callejasantuca methodstoinvestigatethestructureandconnectivityofthenervoussystem
AT loiscarlos methodstoinvestigatethestructureandconnectivityofthenervoussystem

Ejemplares similares