T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

The repeat region of the Plasmodium falciparum circumsporozoite protein (CSP) is a major vaccine antigen because it can be targeted by parasite neutralizing antibodies; however, little is known about this interaction. We used isothermal titration calorimetry, X-ray crystallography and mutagenesis-va...

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Detalles Bibliográficos
Autores principales: Fisher, Camilla R., Sutton, Henry J., Kaczmarski, Joe A., McNamara, Hayley A., Clifton, Ben, Mitchell, Joshua, Cai, Yeping, Dups, Johanna N., D'Arcy, Nicholas J., Singh, Mandeep, Chuah, Aaron, Peat, Thomas S., Jackson, Colin J., Cockburn, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552345/
https://www.ncbi.nlm.nih.gov/pubmed/28759640
http://dx.doi.org/10.1371/journal.ppat.1006469

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