Imidazoquinoxaline anticancer derivatives and imiquimod interact with tubulin: Characterization of molecular microtubule inhibiting mechanisms in correlation with cytotoxicity

Displaying a strong antiproliferative activity on a wide variety of cancer cells, EAPB0203 and EAPB0503 belong to the imidazo[1,2-a]quinoxalines family of imiquimod structural analogues. EAPB0503 has been shown to inhibit tubulin polymerization. The aim of the present study is to characterize the in...

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Detalles Bibliográficos
Autores principales: Courbet, Alexis, Bec, Nicole, Constant, Caroline, Larroque, Christian, Pugniere, Martine, El Messaoudi, Safia, Zghaib, Zahraa, Khier, Sonia, Deleuze-Masquefa, Carine, Gattacceca, Florence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552358/
https://www.ncbi.nlm.nih.gov/pubmed/28797090
http://dx.doi.org/10.1371/journal.pone.0182022

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