An in vivo high-throughput screening for riboswitch ligands using a reverse reporter gene system

Riboswitches are bacterial RNA elements that regulate gene expression in response to metabolite or ion abundance and are considered as potential drug targets. In recent years a number of methods to find non-natural riboswitch ligands have been described. Here we report a high-throughput in vivo scre...

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Detalles Bibliográficos
Autores principales: Kirchner, Marion, Schorpp, Kenji, Hadian, Kamyar, Schneider, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552694/
https://www.ncbi.nlm.nih.gov/pubmed/28798404
http://dx.doi.org/10.1038/s41598-017-07870-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552694/
https://www.ncbi.nlm.nih.gov/pubmed/28798404
http://dx.doi.org/10.1038/s41598-017-07870-w

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