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Understanding the molecular basis of agonist/antagonist mechanism of human mu opioid receptor through gaussian accelerated molecular dynamics method

The most powerful analgesic and addictive properties of opiate alkaloids are mediated by the μ opioid receptor (MOR). The MOR has been extensively investigated as a drug target in the twentieth century, with numerous compounds of varying efficacy being identified. We employed molecular dynamics and...

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Detalles Bibliográficos
Autores principales:	Wang, Yeng-Tseng, Chan, Yang-Hsiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552784/ https://www.ncbi.nlm.nih.gov/pubmed/28798303 http://dx.doi.org/10.1038/s41598-017-08224-2

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