Cargando…

Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study

Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding multi-compon...

Descripción completa

Detalles Bibliográficos
Autores principales: Brandt, Valerie C., Stock, Ann-Kathrin, Münchau, Alexander, Beste, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552788/
https://www.ncbi.nlm.nih.gov/pubmed/28798371
http://dx.doi.org/10.1038/s41598-017-08158-9
_version_ 1783256518392545280
author Brandt, Valerie C.
Stock, Ann-Kathrin
Münchau, Alexander
Beste, Christian
author_facet Brandt, Valerie C.
Stock, Ann-Kathrin
Münchau, Alexander
Beste, Christian
author_sort Brandt, Valerie C.
collection PubMed
description Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding multi-component behaviour was collected from 15 patients with Tourette syndrome (mean age = 30.40 ± 11.10) and 15 healthy controls (27.07 ± 5.44), using the stop-change task. In this task, participants are asked to sometimes withhold responses to a Go stimulus (stop cue) and change hands to respond to an alternative Go stimulus (change cue). Different onset asynchronies between stop and change cues were implemented (0 and 300 ms) in order to vary task difficulty. Tourette patients responded more accurately than healthy controls when there was no delay between stop and change stimulus, while there was no difference in the 300 ms delay condition. This performance advantage was reflected in a smaller P3 event related potential. Enhanced multi-component behaviour in Tourette syndrome is likely based on an enhanced ability to integrate information from multiple sources and translate it into an appropriate response sequence. This may be a consequence of chronic tic control in these patients, or a known fronto-striatal networks hyperconnectivity in Tourette syndrome.
format Online
Article
Text
id pubmed-5552788
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-55527882017-08-14 Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study Brandt, Valerie C. Stock, Ann-Kathrin Münchau, Alexander Beste, Christian Sci Rep Article Evidence suggests that Tourette syndrome is characterized by an increase in dopamine transmission and structural as well as functional changes in fronto-striatal circuits that might lead to enhanced multi-component behaviour integration. Behavioural and neurophysiological data regarding multi-component behaviour was collected from 15 patients with Tourette syndrome (mean age = 30.40 ± 11.10) and 15 healthy controls (27.07 ± 5.44), using the stop-change task. In this task, participants are asked to sometimes withhold responses to a Go stimulus (stop cue) and change hands to respond to an alternative Go stimulus (change cue). Different onset asynchronies between stop and change cues were implemented (0 and 300 ms) in order to vary task difficulty. Tourette patients responded more accurately than healthy controls when there was no delay between stop and change stimulus, while there was no difference in the 300 ms delay condition. This performance advantage was reflected in a smaller P3 event related potential. Enhanced multi-component behaviour in Tourette syndrome is likely based on an enhanced ability to integrate information from multiple sources and translate it into an appropriate response sequence. This may be a consequence of chronic tic control in these patients, or a known fronto-striatal networks hyperconnectivity in Tourette syndrome. Nature Publishing Group UK 2017-08-10 /pmc/articles/PMC5552788/ /pubmed/28798371 http://dx.doi.org/10.1038/s41598-017-08158-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Brandt, Valerie C.
Stock, Ann-Kathrin
Münchau, Alexander
Beste, Christian
Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_full Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_fullStr Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_full_unstemmed Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_short Evidence for enhanced multi-component behaviour in Tourette syndrome – an EEG study
title_sort evidence for enhanced multi-component behaviour in tourette syndrome – an eeg study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552788/
https://www.ncbi.nlm.nih.gov/pubmed/28798371
http://dx.doi.org/10.1038/s41598-017-08158-9
work_keys_str_mv AT brandtvaleriec evidenceforenhancedmulticomponentbehaviourintourettesyndromeaneegstudy
AT stockannkathrin evidenceforenhancedmulticomponentbehaviourintourettesyndromeaneegstudy
AT munchaualexander evidenceforenhancedmulticomponentbehaviourintourettesyndromeaneegstudy
AT bestechristian evidenceforenhancedmulticomponentbehaviourintourettesyndromeaneegstudy