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Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood
Early-life stress in adolescence has a long-lasting influence on brain function in adulthood, and it is mostly recognized as a predisposing factor for mental illnesses, such as anxiety and posttraumatic stress disorder. Previous studies also indicated that adolescent predictable chronic mild stress...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552791/ https://www.ncbi.nlm.nih.gov/pubmed/28798340 http://dx.doi.org/10.1038/s41598-017-08017-7 |
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author | Deng, Jia-Hui Yan, Wei Han, Ying Chen, Chen Meng, Shi-Qiu Sun, Cheng-Yu Xu, Ling-Zhi Xue, Yan-Xue Gao, Xue-Jiao Chen, Na Zhang, Fei-Long Wang, Yu-Mei Shi, Jie Lu, Lin |
author_facet | Deng, Jia-Hui Yan, Wei Han, Ying Chen, Chen Meng, Shi-Qiu Sun, Cheng-Yu Xu, Ling-Zhi Xue, Yan-Xue Gao, Xue-Jiao Chen, Na Zhang, Fei-Long Wang, Yu-Mei Shi, Jie Lu, Lin |
author_sort | Deng, Jia-Hui |
collection | PubMed |
description | Early-life stress in adolescence has a long-lasting influence on brain function in adulthood, and it is mostly recognized as a predisposing factor for mental illnesses, such as anxiety and posttraumatic stress disorder. Previous studies also indicated that adolescent predictable chronic mild stress (PCMS) in early life promotes resilience to depression- and anxiety-like behaviors in adulthood. However, the role of PCMS in associated memory process is still unclear. In the present study, we found that adolescent PCMS facilitated extinction and inhibited fear response in reinstatement and spontaneous recovery tests in adult rats, and this effect was still present 1 week later. PCMS in adolescence increased the activity of brain-derived neurotrophic factor (BDNF)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in infralimbic cortex (IL) but not prelimbic cortex in adulthood. Intra-IL infusion of BDNF antibody and the ERK1/2 inhibitor U0126 reversed PCMS-induced enhancement of fear extinction. Moreover, we found that PCMS decreased DNA methylation of the Bdnf gene at exons IV and VI and elevated the mRNA levels of Bdnf in the IL. Our findings indicate that adolescent PCMS exposure promotes fear memory extinction in adulthood, which reevaluates the traditional notion of adolescent stress. |
format | Online Article Text |
id | pubmed-5552791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55527912017-08-14 Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood Deng, Jia-Hui Yan, Wei Han, Ying Chen, Chen Meng, Shi-Qiu Sun, Cheng-Yu Xu, Ling-Zhi Xue, Yan-Xue Gao, Xue-Jiao Chen, Na Zhang, Fei-Long Wang, Yu-Mei Shi, Jie Lu, Lin Sci Rep Article Early-life stress in adolescence has a long-lasting influence on brain function in adulthood, and it is mostly recognized as a predisposing factor for mental illnesses, such as anxiety and posttraumatic stress disorder. Previous studies also indicated that adolescent predictable chronic mild stress (PCMS) in early life promotes resilience to depression- and anxiety-like behaviors in adulthood. However, the role of PCMS in associated memory process is still unclear. In the present study, we found that adolescent PCMS facilitated extinction and inhibited fear response in reinstatement and spontaneous recovery tests in adult rats, and this effect was still present 1 week later. PCMS in adolescence increased the activity of brain-derived neurotrophic factor (BDNF)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in infralimbic cortex (IL) but not prelimbic cortex in adulthood. Intra-IL infusion of BDNF antibody and the ERK1/2 inhibitor U0126 reversed PCMS-induced enhancement of fear extinction. Moreover, we found that PCMS decreased DNA methylation of the Bdnf gene at exons IV and VI and elevated the mRNA levels of Bdnf in the IL. Our findings indicate that adolescent PCMS exposure promotes fear memory extinction in adulthood, which reevaluates the traditional notion of adolescent stress. Nature Publishing Group UK 2017-08-10 /pmc/articles/PMC5552791/ /pubmed/28798340 http://dx.doi.org/10.1038/s41598-017-08017-7 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Deng, Jia-Hui Yan, Wei Han, Ying Chen, Chen Meng, Shi-Qiu Sun, Cheng-Yu Xu, Ling-Zhi Xue, Yan-Xue Gao, Xue-Jiao Chen, Na Zhang, Fei-Long Wang, Yu-Mei Shi, Jie Lu, Lin Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood |
title | Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood |
title_full | Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood |
title_fullStr | Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood |
title_full_unstemmed | Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood |
title_short | Predictable Chronic Mild Stress during Adolescence Promotes Fear Memory Extinction in Adulthood |
title_sort | predictable chronic mild stress during adolescence promotes fear memory extinction in adulthood |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552791/ https://www.ncbi.nlm.nih.gov/pubmed/28798340 http://dx.doi.org/10.1038/s41598-017-08017-7 |
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