Absence of Grail promotes CD8(+) T cell anti-tumour activity

T-cell tolerance is a major obstacle to successful cancer immunotherapy; thus, developing strategies to break immune tolerance is a high priority. Here we show that expression of the E3 ubiquitin ligase Grail is upregulated in CD8(+) T cells that have infiltrated into transplanted lymphoma tumours,...

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Detalles Bibliográficos
Autores principales: Haymaker, Cara, Yang, Yi, Wang, Junmei, Zou, Qiang, Sahoo, Anupama, Alekseev, Andrei, Singh, Divyendu, Ritthipichai, Krit, Hailemichael, Yared, Hoang, Oanh N., Qin, Hong, Schluns, Kimberly S., Wang, Tiejun, Overwijk, Willem W., Sun, Shao-Cong, Bernatchez, Chantale, Kwak, Larry W., Neelapu, Sattva S., Nurieva, Roza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552797/
https://www.ncbi.nlm.nih.gov/pubmed/28798332
http://dx.doi.org/10.1038/s41467-017-00252-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552797/
https://www.ncbi.nlm.nih.gov/pubmed/28798332
http://dx.doi.org/10.1038/s41467-017-00252-w

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