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Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552878/ https://www.ncbi.nlm.nih.gov/pubmed/28798343 http://dx.doi.org/10.1038/s41598-017-08166-9 |
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author | Antila, Hanna Ryazantseva, Maria Popova, Dina Sipilä, Pia Guirado, Ramon Kohtala, Samuel Yalcin, Ipek Lindholm, Jesse Vesa, Liisa Sato, Vinicius Cordeira, Joshua Autio, Henri Kislin, Mikhail Rios, Maribel Joca, Sâmia Casarotto, Plinio Khiroug, Leonard Lauri, Sari Taira, Tomi Castrén, Eero Rantamäki, Tomi |
author_facet | Antila, Hanna Ryazantseva, Maria Popova, Dina Sipilä, Pia Guirado, Ramon Kohtala, Samuel Yalcin, Ipek Lindholm, Jesse Vesa, Liisa Sato, Vinicius Cordeira, Joshua Autio, Henri Kislin, Mikhail Rios, Maribel Joca, Sâmia Casarotto, Plinio Khiroug, Leonard Lauri, Sari Taira, Tomi Castrén, Eero Rantamäki, Tomi |
author_sort | Antila, Hanna |
collection | PubMed |
description | A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β). Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine. |
format | Online Article Text |
id | pubmed-5552878 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55528782017-08-14 Isoflurane produces antidepressant effects and induces TrkB signaling in rodents Antila, Hanna Ryazantseva, Maria Popova, Dina Sipilä, Pia Guirado, Ramon Kohtala, Samuel Yalcin, Ipek Lindholm, Jesse Vesa, Liisa Sato, Vinicius Cordeira, Joshua Autio, Henri Kislin, Mikhail Rios, Maribel Joca, Sâmia Casarotto, Plinio Khiroug, Leonard Lauri, Sari Taira, Tomi Castrén, Eero Rantamäki, Tomi Sci Rep Article A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β). Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine. Nature Publishing Group UK 2017-08-10 /pmc/articles/PMC5552878/ /pubmed/28798343 http://dx.doi.org/10.1038/s41598-017-08166-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Antila, Hanna Ryazantseva, Maria Popova, Dina Sipilä, Pia Guirado, Ramon Kohtala, Samuel Yalcin, Ipek Lindholm, Jesse Vesa, Liisa Sato, Vinicius Cordeira, Joshua Autio, Henri Kislin, Mikhail Rios, Maribel Joca, Sâmia Casarotto, Plinio Khiroug, Leonard Lauri, Sari Taira, Tomi Castrén, Eero Rantamäki, Tomi Isoflurane produces antidepressant effects and induces TrkB signaling in rodents |
title | Isoflurane produces antidepressant effects and induces TrkB signaling in rodents |
title_full | Isoflurane produces antidepressant effects and induces TrkB signaling in rodents |
title_fullStr | Isoflurane produces antidepressant effects and induces TrkB signaling in rodents |
title_full_unstemmed | Isoflurane produces antidepressant effects and induces TrkB signaling in rodents |
title_short | Isoflurane produces antidepressant effects and induces TrkB signaling in rodents |
title_sort | isoflurane produces antidepressant effects and induces trkb signaling in rodents |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552878/ https://www.ncbi.nlm.nih.gov/pubmed/28798343 http://dx.doi.org/10.1038/s41598-017-08166-9 |
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