Cargando…

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the...

Descripción completa

Detalles Bibliográficos
Autores principales: Antila, Hanna, Ryazantseva, Maria, Popova, Dina, Sipilä, Pia, Guirado, Ramon, Kohtala, Samuel, Yalcin, Ipek, Lindholm, Jesse, Vesa, Liisa, Sato, Vinicius, Cordeira, Joshua, Autio, Henri, Kislin, Mikhail, Rios, Maribel, Joca, Sâmia, Casarotto, Plinio, Khiroug, Leonard, Lauri, Sari, Taira, Tomi, Castrén, Eero, Rantamäki, Tomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552878/
https://www.ncbi.nlm.nih.gov/pubmed/28798343
http://dx.doi.org/10.1038/s41598-017-08166-9
_version_ 1783256540338192384
author Antila, Hanna
Ryazantseva, Maria
Popova, Dina
Sipilä, Pia
Guirado, Ramon
Kohtala, Samuel
Yalcin, Ipek
Lindholm, Jesse
Vesa, Liisa
Sato, Vinicius
Cordeira, Joshua
Autio, Henri
Kislin, Mikhail
Rios, Maribel
Joca, Sâmia
Casarotto, Plinio
Khiroug, Leonard
Lauri, Sari
Taira, Tomi
Castrén, Eero
Rantamäki, Tomi
author_facet Antila, Hanna
Ryazantseva, Maria
Popova, Dina
Sipilä, Pia
Guirado, Ramon
Kohtala, Samuel
Yalcin, Ipek
Lindholm, Jesse
Vesa, Liisa
Sato, Vinicius
Cordeira, Joshua
Autio, Henri
Kislin, Mikhail
Rios, Maribel
Joca, Sâmia
Casarotto, Plinio
Khiroug, Leonard
Lauri, Sari
Taira, Tomi
Castrén, Eero
Rantamäki, Tomi
author_sort Antila, Hanna
collection PubMed
description A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β). Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine.
format Online
Article
Text
id pubmed-5552878
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-55528782017-08-14 Isoflurane produces antidepressant effects and induces TrkB signaling in rodents Antila, Hanna Ryazantseva, Maria Popova, Dina Sipilä, Pia Guirado, Ramon Kohtala, Samuel Yalcin, Ipek Lindholm, Jesse Vesa, Liisa Sato, Vinicius Cordeira, Joshua Autio, Henri Kislin, Mikhail Rios, Maribel Joca, Sâmia Casarotto, Plinio Khiroug, Leonard Lauri, Sari Taira, Tomi Castrén, Eero Rantamäki, Tomi Sci Rep Article A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned helplessness paradigm and regulates molecular events implicated in the mechanism of action of rapid-acting antidepressant ketamine: activation of brain-derived neurotrophic factor (BDNF) receptor TrkB, facilitation of mammalian target of rapamycin (mTOR) signaling pathway and inhibition of glycogen synthase kinase 3β (GSK3β). Moreover, isoflurane affected neuronal plasticity by facilitating long-term potentiation in the hippocampus. We also found that isoflurane increased activity of the parvalbumin interneurons, and facilitated GABAergic transmission in wild type mice but not in transgenic mice with reduced TrkB expression in parvalbumin interneurons. Our findings strengthen the role of TrkB signaling in the antidepressant responses and encourage further evaluation of isoflurane as a rapid-acting antidepressant devoid of the psychotomimetic effects and abuse potential of ketamine. Nature Publishing Group UK 2017-08-10 /pmc/articles/PMC5552878/ /pubmed/28798343 http://dx.doi.org/10.1038/s41598-017-08166-9 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Antila, Hanna
Ryazantseva, Maria
Popova, Dina
Sipilä, Pia
Guirado, Ramon
Kohtala, Samuel
Yalcin, Ipek
Lindholm, Jesse
Vesa, Liisa
Sato, Vinicius
Cordeira, Joshua
Autio, Henri
Kislin, Mikhail
Rios, Maribel
Joca, Sâmia
Casarotto, Plinio
Khiroug, Leonard
Lauri, Sari
Taira, Tomi
Castrén, Eero
Rantamäki, Tomi
Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
title Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
title_full Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
title_fullStr Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
title_full_unstemmed Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
title_short Isoflurane produces antidepressant effects and induces TrkB signaling in rodents
title_sort isoflurane produces antidepressant effects and induces trkb signaling in rodents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552878/
https://www.ncbi.nlm.nih.gov/pubmed/28798343
http://dx.doi.org/10.1038/s41598-017-08166-9
work_keys_str_mv AT antilahanna isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT ryazantsevamaria isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT popovadina isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT sipilapia isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT guiradoramon isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT kohtalasamuel isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT yalcinipek isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT lindholmjesse isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT vesaliisa isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT satovinicius isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT cordeirajoshua isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT autiohenri isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT kislinmikhail isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT riosmaribel isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT jocasamia isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT casarottoplinio isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT khirougleonard isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT laurisari isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT tairatomi isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT castreneero isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents
AT rantamakitomi isofluraneproducesantidepressanteffectsandinducestrkbsignalinginrodents