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Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria

Most antibiotics are derived from the soil, but their catabolism there, which is necessary to close the antibiotic carbon cycle, remains uncharacterized. We report the first draft genome sequences of soil Proteobacteria identified for subsisting solely on β-lactams as their carbon sources. The genom...

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Autores principales: Crofts, Terence S., Wang, Bin, Spivak, Aaron, Gianoulis, Tara A., Forsberg, Kevin J., Gibson, Molly K., Johnsky, Lauren A., Broomall, Stacey M., Rosenzweig, C. Nicole, Skowronski, Evan W., Gibbons, Henry S., Sommer, Morten O. A., Dantas, Gautam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552975/
https://www.ncbi.nlm.nih.gov/pubmed/28798166
http://dx.doi.org/10.1128/genomeA.00653-17
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author Crofts, Terence S.
Wang, Bin
Spivak, Aaron
Gianoulis, Tara A.
Forsberg, Kevin J.
Gibson, Molly K.
Johnsky, Lauren A.
Broomall, Stacey M.
Rosenzweig, C. Nicole
Skowronski, Evan W.
Gibbons, Henry S.
Sommer, Morten O. A.
Dantas, Gautam
author_facet Crofts, Terence S.
Wang, Bin
Spivak, Aaron
Gianoulis, Tara A.
Forsberg, Kevin J.
Gibson, Molly K.
Johnsky, Lauren A.
Broomall, Stacey M.
Rosenzweig, C. Nicole
Skowronski, Evan W.
Gibbons, Henry S.
Sommer, Morten O. A.
Dantas, Gautam
author_sort Crofts, Terence S.
collection PubMed
description Most antibiotics are derived from the soil, but their catabolism there, which is necessary to close the antibiotic carbon cycle, remains uncharacterized. We report the first draft genome sequences of soil Proteobacteria identified for subsisting solely on β-lactams as their carbon sources. The genomes encode multiple β-lactamases, although their antibiotic catabolic pathways remain enigmatic.
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spelling pubmed-55529752017-08-25 Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria Crofts, Terence S. Wang, Bin Spivak, Aaron Gianoulis, Tara A. Forsberg, Kevin J. Gibson, Molly K. Johnsky, Lauren A. Broomall, Stacey M. Rosenzweig, C. Nicole Skowronski, Evan W. Gibbons, Henry S. Sommer, Morten O. A. Dantas, Gautam Genome Announc Prokaryotes Most antibiotics are derived from the soil, but their catabolism there, which is necessary to close the antibiotic carbon cycle, remains uncharacterized. We report the first draft genome sequences of soil Proteobacteria identified for subsisting solely on β-lactams as their carbon sources. The genomes encode multiple β-lactamases, although their antibiotic catabolic pathways remain enigmatic. American Society for Microbiology 2017-08-10 /pmc/articles/PMC5552975/ /pubmed/28798166 http://dx.doi.org/10.1128/genomeA.00653-17 Text en Copyright © 2017 Crofts et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Prokaryotes
Crofts, Terence S.
Wang, Bin
Spivak, Aaron
Gianoulis, Tara A.
Forsberg, Kevin J.
Gibson, Molly K.
Johnsky, Lauren A.
Broomall, Stacey M.
Rosenzweig, C. Nicole
Skowronski, Evan W.
Gibbons, Henry S.
Sommer, Morten O. A.
Dantas, Gautam
Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria
title Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria
title_full Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria
title_fullStr Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria
title_full_unstemmed Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria
title_short Draft Genome Sequences of Three β-Lactam-Catabolizing Soil Proteobacteria
title_sort draft genome sequences of three β-lactam-catabolizing soil proteobacteria
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5552975/
https://www.ncbi.nlm.nih.gov/pubmed/28798166
http://dx.doi.org/10.1128/genomeA.00653-17
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