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Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016

Robust data on hepatitis C virus (HCV) population prevalence are essential to inform national HCV services. In 2016, we undertook a survey to estimate HCV prevalence among the adult population in Ireland. We used anonymised residual sera available at the National Virus Reference Laboratory. We selec...

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Autores principales: Garvey, Patricia, O'Grady, Brian, Franzoni, Geraldine, Bolger, Maeve, Irwin Crosby, Katie, Connell, Jeff, Burke, Deirdre, De Gascun, Cillian, Thornton, Lelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553053/
https://www.ncbi.nlm.nih.gov/pubmed/28797323
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.30.30579
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author Garvey, Patricia
O'Grady, Brian
Franzoni, Geraldine
Bolger, Maeve
Irwin Crosby, Katie
Connell, Jeff
Burke, Deirdre
De Gascun, Cillian
Thornton, Lelia
author_facet Garvey, Patricia
O'Grady, Brian
Franzoni, Geraldine
Bolger, Maeve
Irwin Crosby, Katie
Connell, Jeff
Burke, Deirdre
De Gascun, Cillian
Thornton, Lelia
author_sort Garvey, Patricia
collection PubMed
description Robust data on hepatitis C virus (HCV) population prevalence are essential to inform national HCV services. In 2016, we undertook a survey to estimate HCV prevalence among the adult population in Ireland. We used anonymised residual sera available at the National Virus Reference Laboratory. We selected a random sample comprising persons ≥ 18 years with probability proportional to the general population age-sex distribution. Anti-HCV and HCV Ag were determined using the Architect anti-HCV and HCV Ag assays. Fifty-three of 3,795 specimens were seropositive (age-sex-area weighted seroprevalence 0.98% (95% confidence interval (CI): 0.73–1.3%)). Thirty-three specimens were HCV-antigen and antibody-positive (age-sex-area weighted prevalence of chronic infection 0.57% (95% CI: 0.40–0.81%)). The prevalence of chronic infection was higher in men (0.91%; 95% CI: 0.61–1.4%), in specimens from the east of the country (1.4%; 95%CI: 0.99–2.0%), and among persons aged 30–39 years and 40–49 years (1.1% (95% CI: 0.59–2.0%) and 1.1% (95% CI: 0.64–1.9%) respectively). Ireland ranks at the lower end of the spectrum of prevalence of chronic HCV infection internationally. Men born between 1965 and 1984 from the east of the country have the highest rate of chronic HCV infection.
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spelling pubmed-55530532017-08-28 Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016 Garvey, Patricia O'Grady, Brian Franzoni, Geraldine Bolger, Maeve Irwin Crosby, Katie Connell, Jeff Burke, Deirdre De Gascun, Cillian Thornton, Lelia Euro Surveill Research Article Robust data on hepatitis C virus (HCV) population prevalence are essential to inform national HCV services. In 2016, we undertook a survey to estimate HCV prevalence among the adult population in Ireland. We used anonymised residual sera available at the National Virus Reference Laboratory. We selected a random sample comprising persons ≥ 18 years with probability proportional to the general population age-sex distribution. Anti-HCV and HCV Ag were determined using the Architect anti-HCV and HCV Ag assays. Fifty-three of 3,795 specimens were seropositive (age-sex-area weighted seroprevalence 0.98% (95% confidence interval (CI): 0.73–1.3%)). Thirty-three specimens were HCV-antigen and antibody-positive (age-sex-area weighted prevalence of chronic infection 0.57% (95% CI: 0.40–0.81%)). The prevalence of chronic infection was higher in men (0.91%; 95% CI: 0.61–1.4%), in specimens from the east of the country (1.4%; 95%CI: 0.99–2.0%), and among persons aged 30–39 years and 40–49 years (1.1% (95% CI: 0.59–2.0%) and 1.1% (95% CI: 0.64–1.9%) respectively). Ireland ranks at the lower end of the spectrum of prevalence of chronic HCV infection internationally. Men born between 1965 and 1984 from the east of the country have the highest rate of chronic HCV infection. European Centre for Disease Prevention and Control (ECDC) 2017-07-27 /pmc/articles/PMC5553053/ /pubmed/28797323 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.30.30579 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Garvey, Patricia
O'Grady, Brian
Franzoni, Geraldine
Bolger, Maeve
Irwin Crosby, Katie
Connell, Jeff
Burke, Deirdre
De Gascun, Cillian
Thornton, Lelia
Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016
title Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016
title_full Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016
title_fullStr Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016
title_full_unstemmed Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016
title_short Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016
title_sort hepatitis c virus seroprevalence and prevalence of chronic infection in the adult population in ireland: a study of residual sera, april 2014 to february 2016
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553053/
https://www.ncbi.nlm.nih.gov/pubmed/28797323
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.30.30579
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