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2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project

We conducted a multicentre test-negative case–control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compati...

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Autores principales: Rondy, Marc, Larrauri, Amparo, Casado, Itziar, Alfonsi, Valeria, Pitigoi, Daniela, Launay, Odile, Syrjänen, Ritva K, Gefenaite, Giedre, Machado, Ausenda, Vučina, Vesna Višekruna, Horváth, Judith Krisztina, Paradowska-Stankiewicz, Iwona, Marbus, Sierk D, Gherasim, Alin, Díaz-González, Jorge Alberto, Rizzo, Caterina, Ivanciuc, Alina E, Galtier, Florence, Ikonen, Niina, Mickiene, Aukse, Gomez, Veronica, Kurečić Filipović, Sanja, Ferenczi, Annamária, Korcinska, Monika R, van Gageldonk-Lafeber, Rianne, Valenciano, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553054/
https://www.ncbi.nlm.nih.gov/pubmed/28797322
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.30.30580
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author Rondy, Marc
Larrauri, Amparo
Casado, Itziar
Alfonsi, Valeria
Pitigoi, Daniela
Launay, Odile
Syrjänen, Ritva K
Gefenaite, Giedre
Machado, Ausenda
Vučina, Vesna Višekruna
Horváth, Judith Krisztina
Paradowska-Stankiewicz, Iwona
Marbus, Sierk D
Gherasim, Alin
Díaz-González, Jorge Alberto
Rizzo, Caterina
Ivanciuc, Alina E
Galtier, Florence
Ikonen, Niina
Mickiene, Aukse
Gomez, Veronica
Kurečić Filipović, Sanja
Ferenczi, Annamária
Korcinska, Monika R
van Gageldonk-Lafeber, Rianne
Valenciano, Marta
author_facet Rondy, Marc
Larrauri, Amparo
Casado, Itziar
Alfonsi, Valeria
Pitigoi, Daniela
Launay, Odile
Syrjänen, Ritva K
Gefenaite, Giedre
Machado, Ausenda
Vučina, Vesna Višekruna
Horváth, Judith Krisztina
Paradowska-Stankiewicz, Iwona
Marbus, Sierk D
Gherasim, Alin
Díaz-González, Jorge Alberto
Rizzo, Caterina
Ivanciuc, Alina E
Galtier, Florence
Ikonen, Niina
Mickiene, Aukse
Gomez, Veronica
Kurečić Filipović, Sanja
Ferenczi, Annamária
Korcinska, Monika R
van Gageldonk-Lafeber, Rianne
Valenciano, Marta
author_sort Rondy, Marc
collection PubMed
description We conducted a multicentre test-negative case–control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases.
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spelling pubmed-55530542017-08-28 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project Rondy, Marc Larrauri, Amparo Casado, Itziar Alfonsi, Valeria Pitigoi, Daniela Launay, Odile Syrjänen, Ritva K Gefenaite, Giedre Machado, Ausenda Vučina, Vesna Višekruna Horváth, Judith Krisztina Paradowska-Stankiewicz, Iwona Marbus, Sierk D Gherasim, Alin Díaz-González, Jorge Alberto Rizzo, Caterina Ivanciuc, Alina E Galtier, Florence Ikonen, Niina Mickiene, Aukse Gomez, Veronica Kurečić Filipović, Sanja Ferenczi, Annamária Korcinska, Monika R van Gageldonk-Lafeber, Rianne Valenciano, Marta Euro Surveill Research Article We conducted a multicentre test-negative case–control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders. We included 355 influenza A(H1N1)pdm09 cases, 110 influenza B cases, and 1,274 controls. Adjusted IVE against influenza A(H1N1)pdm09 was 42% (95% confidence interval (CI): 22 to 57). It was 59% (95% CI: 23 to 78), 48% (95% CI: 5 to 71), 43% (95% CI: 8 to 65) and 39% (95% CI: 7 to 60) in patients with diabetes mellitus, cancer, lung and heart disease, respectively. Adjusted IVE against influenza B was 52% (95% CI: 24 to 70). It was 62% (95% CI: 5 to 85), 60% (95% CI: 18 to 80) and 36% (95% CI: -23 to 67) in patients with diabetes mellitus, lung and heart disease, respectively. 2015/16 IVE estimates against hospitalised influenza in elderly people was moderate against influenza A(H1N1)pdm09 and B, including among those with diabetes mellitus, cancer, lung or heart diseases. European Centre for Disease Prevention and Control (ECDC) 2017-07-27 /pmc/articles/PMC5553054/ /pubmed/28797322 http://dx.doi.org/10.2807/1560-7917.ES.2017.22.30.30580 Text en This article is copyright of The Authors, 2017. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Research Article
Rondy, Marc
Larrauri, Amparo
Casado, Itziar
Alfonsi, Valeria
Pitigoi, Daniela
Launay, Odile
Syrjänen, Ritva K
Gefenaite, Giedre
Machado, Ausenda
Vučina, Vesna Višekruna
Horváth, Judith Krisztina
Paradowska-Stankiewicz, Iwona
Marbus, Sierk D
Gherasim, Alin
Díaz-González, Jorge Alberto
Rizzo, Caterina
Ivanciuc, Alina E
Galtier, Florence
Ikonen, Niina
Mickiene, Aukse
Gomez, Veronica
Kurečić Filipović, Sanja
Ferenczi, Annamária
Korcinska, Monika R
van Gageldonk-Lafeber, Rianne
Valenciano, Marta
2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project
title 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project
title_full 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project
title_fullStr 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project
title_full_unstemmed 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project
title_short 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza A(H1N1)pdm09 and B among elderly people in Europe: results from the I-MOVE+ project
title_sort 2015/16 seasonal vaccine effectiveness against hospitalisation with influenza a(h1n1)pdm09 and b among elderly people in europe: results from the i-move+ project
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553054/
https://www.ncbi.nlm.nih.gov/pubmed/28797322
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.30.30580
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