Detecting Gene Rearrangements in Patient Populations Through a 2-Step Diagnostic Test Comprised of Rapid IHC Enrichment Followed by Sensitive Next-Generation Sequencing

Targeted therapy combined with companion diagnostics has led to the advancement of next-generation sequencing (NGS) for detection of molecular alterations. However, using a diagnostic test to identify patient populations with low prevalence molecular alterations, such as gene rearrangements, poses e...

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Detalles Bibliográficos
Autores principales: Murphy, Danielle A., Ely, Heather A., Shoemaker, Robert, Boomer, Aaron, Culver, Brady P., Hoskins, Ian, Haimes, Josh D., Walters, Ryan D., Fernandez, Diane, Stahl, Joshua A., Lee, Jeeyun, Kim, Kyoung-Mee, Lamoureux, Jennifer, Christiansen, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553231/
https://www.ncbi.nlm.nih.gov/pubmed/27028240
http://dx.doi.org/10.1097/PAI.0000000000000360

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553231/
https://www.ncbi.nlm.nih.gov/pubmed/27028240
http://dx.doi.org/10.1097/PAI.0000000000000360

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