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Application of three-dimensional printing for colon targeted drug delivery systems

Orally administered solid dosage forms currently dominate over all other dosage forms and routes of administrations. However, human gastrointestinal tract (GIT) poses a number of obstacles to delivery of the drugs to the site of interest and absorption in the GIT. Pharmaceutical scientists worldwide...

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Autores principales: Charbe, Nitin B., McCarron, Paul A., Lane, Majella E., Tambuwala, Murtaza M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553264/
https://www.ncbi.nlm.nih.gov/pubmed/28929046
http://dx.doi.org/10.4103/jphi.JPHI_32_17
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author Charbe, Nitin B.
McCarron, Paul A.
Lane, Majella E.
Tambuwala, Murtaza M.
author_facet Charbe, Nitin B.
McCarron, Paul A.
Lane, Majella E.
Tambuwala, Murtaza M.
author_sort Charbe, Nitin B.
collection PubMed
description Orally administered solid dosage forms currently dominate over all other dosage forms and routes of administrations. However, human gastrointestinal tract (GIT) poses a number of obstacles to delivery of the drugs to the site of interest and absorption in the GIT. Pharmaceutical scientists worldwide have been interested in colon drug delivery for several decades, not only for the delivery of the drugs for the treatment of colonic diseases such as ulcerative colitis and colon cancer but also for delivery of therapeutic proteins and peptides for systemic absorption. Despite extensive research in the area of colon targeted drug delivery, we have not been able to come up with an effective way of delivering drugs to the colon. The current tablets designed for colon drug release depend on either pH-dependent or time-delayed release formulations. During ulcerative colitis the gastric transit time and colon pH-levels is constantly changing depending on whether the patient is having a relapse or under remission. Hence, the current drug delivery system to the colon is based on one-size-fits-all. Fails to effectively deliver the drugs locally to the colon for colonic diseases and delivery of therapeutic proteins and peptides for systemic absorption from the colon. Hence, to overcome the current issues associated with colon drug delivery, we need to provide the patients with personalized tablets which are specifically designed to match the individual's gastric transit time depending on the disease state. Three-dimensional (3D) printing (3DP) technology is getting cheaper by the day and bespoke manufacturing of 3D-printed tablets could provide the solutions in the form of personalized colon drug delivery system. This review provides a bird's eye view of applications and current advances in pharmaceutical 3DP with emphasis on the development of colon targeted drug delivery systems.
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spelling pubmed-55532642017-09-19 Application of three-dimensional printing for colon targeted drug delivery systems Charbe, Nitin B. McCarron, Paul A. Lane, Majella E. Tambuwala, Murtaza M. Int J Pharm Investig Review Article Orally administered solid dosage forms currently dominate over all other dosage forms and routes of administrations. However, human gastrointestinal tract (GIT) poses a number of obstacles to delivery of the drugs to the site of interest and absorption in the GIT. Pharmaceutical scientists worldwide have been interested in colon drug delivery for several decades, not only for the delivery of the drugs for the treatment of colonic diseases such as ulcerative colitis and colon cancer but also for delivery of therapeutic proteins and peptides for systemic absorption. Despite extensive research in the area of colon targeted drug delivery, we have not been able to come up with an effective way of delivering drugs to the colon. The current tablets designed for colon drug release depend on either pH-dependent or time-delayed release formulations. During ulcerative colitis the gastric transit time and colon pH-levels is constantly changing depending on whether the patient is having a relapse or under remission. Hence, the current drug delivery system to the colon is based on one-size-fits-all. Fails to effectively deliver the drugs locally to the colon for colonic diseases and delivery of therapeutic proteins and peptides for systemic absorption from the colon. Hence, to overcome the current issues associated with colon drug delivery, we need to provide the patients with personalized tablets which are specifically designed to match the individual's gastric transit time depending on the disease state. Three-dimensional (3D) printing (3DP) technology is getting cheaper by the day and bespoke manufacturing of 3D-printed tablets could provide the solutions in the form of personalized colon drug delivery system. This review provides a bird's eye view of applications and current advances in pharmaceutical 3DP with emphasis on the development of colon targeted drug delivery systems. Medknow Publications & Media Pvt Ltd 2017 /pmc/articles/PMC5553264/ /pubmed/28929046 http://dx.doi.org/10.4103/jphi.JPHI_32_17 Text en Copyright: © 2017 International Journal of Pharmaceutical Investigation http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Charbe, Nitin B.
McCarron, Paul A.
Lane, Majella E.
Tambuwala, Murtaza M.
Application of three-dimensional printing for colon targeted drug delivery systems
title Application of three-dimensional printing for colon targeted drug delivery systems
title_full Application of three-dimensional printing for colon targeted drug delivery systems
title_fullStr Application of three-dimensional printing for colon targeted drug delivery systems
title_full_unstemmed Application of three-dimensional printing for colon targeted drug delivery systems
title_short Application of three-dimensional printing for colon targeted drug delivery systems
title_sort application of three-dimensional printing for colon targeted drug delivery systems
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553264/
https://www.ncbi.nlm.nih.gov/pubmed/28929046
http://dx.doi.org/10.4103/jphi.JPHI_32_17
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