Recurrent SERPINB3 and SERPINB4 Mutations in Patients that Respond to Anti-CTLA4 Immunotherapy

Immune checkpoint blockade has shown significant promise as an anti-cancer treatment, yet the determinants of response are not completely understood. Here, we show that somatic mutations in SERPINB3 and SERPINB4 are associated with survival following anti-CTLA4 immunotherapy in two independent cohor...

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Autores principales: Riaz, Nadeem, Havel, Jonathan J., Kendall, Sviatoslav M., Makarov, Vladimir, Walsh, Logan A., Desrichard, Alexis, Weinhold, Nils, Chan, Timothy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553281/
https://www.ncbi.nlm.nih.gov/pubmed/27668655
http://dx.doi.org/10.1038/ng.3677
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author Riaz, Nadeem
Havel, Jonathan J.
Kendall, Sviatoslav M.
Makarov, Vladimir
Walsh, Logan A.
Desrichard, Alexis
Weinhold, Nils
Chan, Timothy A.
author_facet Riaz, Nadeem
Havel, Jonathan J.
Kendall, Sviatoslav M.
Makarov, Vladimir
Walsh, Logan A.
Desrichard, Alexis
Weinhold, Nils
Chan, Timothy A.
author_sort Riaz, Nadeem
collection PubMed
description Immune checkpoint blockade has shown significant promise as an anti-cancer treatment, yet the determinants of response are not completely understood. Here, we show that somatic mutations in SERPINB3 and SERPINB4 are associated with survival following anti-CTLA4 immunotherapy in two independent cohorts of melanoma patients (n=174). Interestingly, serpins are homologues of the well-known ovalbumin antigen and are associated with autoimmunity. Our findings have implications for the personalization of immunotherapy.
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spelling pubmed-55532812017-08-11 Recurrent SERPINB3 and SERPINB4 Mutations in Patients that Respond to Anti-CTLA4 Immunotherapy Riaz, Nadeem Havel, Jonathan J. Kendall, Sviatoslav M. Makarov, Vladimir Walsh, Logan A. Desrichard, Alexis Weinhold, Nils Chan, Timothy A. Nat Genet Article Immune checkpoint blockade has shown significant promise as an anti-cancer treatment, yet the determinants of response are not completely understood. Here, we show that somatic mutations in SERPINB3 and SERPINB4 are associated with survival following anti-CTLA4 immunotherapy in two independent cohorts of melanoma patients (n=174). Interestingly, serpins are homologues of the well-known ovalbumin antigen and are associated with autoimmunity. Our findings have implications for the personalization of immunotherapy. 2016-09-26 2016-11 /pmc/articles/PMC5553281/ /pubmed/27668655 http://dx.doi.org/10.1038/ng.3677 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Riaz, Nadeem
Havel, Jonathan J.
Kendall, Sviatoslav M.
Makarov, Vladimir
Walsh, Logan A.
Desrichard, Alexis
Weinhold, Nils
Chan, Timothy A.
Recurrent SERPINB3 and SERPINB4 Mutations in Patients that Respond to Anti-CTLA4 Immunotherapy
title Recurrent SERPINB3 and SERPINB4 Mutations in Patients that Respond to Anti-CTLA4 Immunotherapy
title_full Recurrent SERPINB3 and SERPINB4 Mutations in Patients that Respond to Anti-CTLA4 Immunotherapy
title_fullStr Recurrent SERPINB3 and SERPINB4 Mutations in Patients that Respond to Anti-CTLA4 Immunotherapy
title_full_unstemmed Recurrent SERPINB3 and SERPINB4 Mutations in Patients that Respond to Anti-CTLA4 Immunotherapy
title_short Recurrent SERPINB3 and SERPINB4 Mutations in Patients that Respond to Anti-CTLA4 Immunotherapy
title_sort recurrent serpinb3 and serpinb4 mutations in patients that respond to anti-ctla4 immunotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553281/
https://www.ncbi.nlm.nih.gov/pubmed/27668655
http://dx.doi.org/10.1038/ng.3677
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