Cargando…

Suppressive effects of RXR agonist PA024 on adrenal CYP11B2 expression, aldosterone secretion and blood pressure

The effects of retinoids on adrenal aldosterone synthase gene (CYP11B2) expression and aldosterone secretion are still unknown. We therefore examined the effects of nuclear retinoid X receptor (RXR) pan-agonist PA024 on CYP11B2 expression, aldosterone secretion and blood pressure, to elucidate its p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Suzuki, Dai, Saito-Hakoda, Akiko, Ito, Ryo, Shimizu, Kyoko, Parvin, Rehana, Shimada, Hiroki, Noro, Erika, Suzuki, Susumu, Fujiwara, Ikuma, Kagechika, Hiroyuki, Rainey, William E., Kure, Shigeo, Ito, Sadayoshi, Yokoyama, Atsushi, Sugawara, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553648/ https://www.ncbi.nlm.nih.gov/pubmed/28800627 http://dx.doi.org/10.1371/journal.pone.0181055

Ejemplares similares

Effects of RXR Agonists on Cell Proliferation/Apoptosis and ACTH Secretion/Pomc Expression
por: Saito-Hakoda, Akiko, et al.
Publicado: (2015)

High glucose stimulates expression of aldosterone synthase (CYP11B2) and secretion of aldosterone in human adrenal cells
por: Shimada, Hiroki, et al.
Publicado: (2017)

Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells
por: Parvin, Rehana, et al.
Publicado: (2018)

Nateglinide is Effective for Diabetes Mellitus with Reactive Hypoglycemia in a Child with a Compound Heterozygous ABCC8 Mutation
por: Saito-Hakoda, Akiko, et al.
Publicado: (2012)

Progress in the Management of Primary Aldosteronism
por: Morimoto, Ryo, et al.
Publicado: (2018)

SAT-058 Histopathological Analysis of Kidneys and Adrenal Glands in the Same Primary Aldosteronism (PA) Patients: Exploring the Mechanisms of Aldosterone Specific Renal Injuries
por: Ogata, Hiroko, et al.
Publicado: (2019)

LBODP025 A Novel Drug Discovery For Primary Aldosteronism Targeting Aldosterone Synthase (cyp11b2) And Kcnj5 Mutant
por: Otsubo, Yuri, et al.
Publicado: (2022)

Brain White Matter Abnormality in a Newborn Infant with Congenital Adrenal Hyperplasia
por: Kaga, Akimune, et al.
Publicado: (2013)

A follow-up during puberty in a Japanese girl with type A insulin resistance due to a novel mutation in INSR
por: Saito-Hakoda, Akiko, et al.
Publicado: (2018)

Primary aldosteronism: A Japanese perspective
por: Satoh, Fumitoshi, et al.
Publicado: (2011)

Endogenous Purification of NR4A2 (Nurr1) Identified Poly(ADP-Ribose) Polymerase 1 as a Prime Coregulator in Human Adrenocortical H295R Cells
por: Noro, Erika, et al.
Publicado: (2018)

Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals
por: Omata, Kei, et al.
Publicado: (2017)

RAR/RXR and PPAR/RXR Signaling in Spinal Cord Injury
por: van Neerven, Sabien, et al.
Publicado: (2007)

Regulation of RXR-RAR Heterodimers by RXR- and RAR-Specific Ligands and Their Combinations
por: le Maire, Albane, et al.
Publicado: (2019)

Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization
por: Scheepstra, Marcel, et al.
Publicado: (2017)

Aromatase expression and outcomes in the P024 neoadjuvant endocrine therapy trial
por: Ellis, Matthew J., et al.
Publicado: (2008)

Spatially restricted substrate-binding site of cortisol-synthesizing CYP11B1 limits multiple hydroxylations and hinders aldosterone synthesis
por: Mukai, Kuniaki, et al.
Publicado: (2021)

Masking by hypokalemia—primary aldosteronism with undetectable aldosterone
por: Boyle, Rebecca A, et al.
Publicado: (2020)

Aldosterone-Regulating Receptors and Aldosterone-Driver Somatic Mutations
por: Lim, Jung Soo, et al.
Publicado: (2021)

Analysis of RXR/THR and RXR/PPARG2 Heterodimerization by Bioluminescence Resonance Energy Transfer (BRET)
por: Mulero, Miquel, et al.
Publicado: (2013)

Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations
por: Jones, Patrice, et al.
Publicado: (2020)

Letrozole in the neoadjuvant setting: the P024 trial
por: Ellis, Matthew J., et al.
Publicado: (2007)

Letrozole in the neoadjuvant setting the P024 trial
por: Ellis, Matthew J., et al.
Publicado: (2007)

SAT-063 Peripheral Aldosterone Values During Simultaneous Bilateral Adrenal Veins Sampling (AVS) to Predict the Source of Aldosterone Secretion in Primary Aldosteronism (PA)
por: St-Jean, Matthieu, et al.
Publicado: (2019)

Acute Kidney Injury from Excessive Potentiation of Calcium-channel Blocker via Synergistic CYP3A4 Inhibition by Clarithromycin Plus Voriconazole
por: Mishima, Eikan, et al.
Publicado: (2017)

YM750, an ACAT Inhibitor, Acts on Adrenocortical Cells to Inhibit Aldosterone Secretion Due to Depolarization
por: Shimada, Hiroki, et al.
Publicado: (2022)

CMS ARDA Meeting, ARDA-Note-2004-024
por: CERN. Geneva
Publicado: (2004)

Efficacy and safety of esaxerenone (CS-3150), a newly available nonsteroidal mineralocorticoid receptor blocker, in hypertensive patients with primary aldosteronism
por: Satoh, Fumitoshi, et al.
Publicado: (2020)

Relationship of Ocular Microcirculation, Measured by Laser Speckle Flowgraphy, and Silent Brain Infarction in Primary Aldosteronism
por: Kunikata, Hiroshi, et al.
Publicado: (2015)

RXR Ligands Negatively Regulate Thrombosis and Hemostasis
por: Unsworth, Amanda J., et al.
Publicado: (2017)

The Occurrence of Apparent Bilateral Aldosterone Suppression in Adrenal Vein Sampling for Primary Aldosteronism
por: Shibayama, Yui, et al.
Publicado: (2018)

P03-024 – Early onset IBD treated by tocilizumab
por: Helbling, R, et al.
Publicado: (2013)

Molecular and Epigenetic Control of Aldosterone Synthase, CYP11B2 and 11-Hydroxylase, CYP11B1
por: Takeda, Yoshimichi, et al.
Publicado: (2023)

SAT-544 Primary Aldosteronism in Intracerebral Hemorrhage. Not Intracerebral Hemorrhage in Primary Aldosteronism
por: Arai, Makoto, et al.
Publicado: (2020)

The Role of the CYP11B2 Promoter Polymorphism in the Diagnosis of Primary Aldosteronism
por: Żukowski, Łukasz, et al.
Publicado: (2020)

Laterality Diagnosis of Adrenal Vein Sampling for Primary Aldosteronism Using Aldosterone Alone
por: Wada, Norio, et al.
Publicado: (2021)

Molecular Evolution of Ultraspiracle Protein (USP/RXR) in Insects
por: Hult, Ekaterina F., et al.
Publicado: (2011)

RXRα Regulates the Development of Resident Tissue Macrophages
por: Philpott, Jordan, et al.
Publicado: (2022)

PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid ω-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease
por: Hardwick, James P., et al.
Publicado: (2009)

Urinary stones resembling uric acid stones
por: Tanemoto, Masayuki, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_4jgolpdah8qqfhthp3256e27ns