Coronavirus mRNA synthesis involves fusion of non-contiguous sequences.

Positive-stranded genomic RNA of coronavirus MHV and its six subgenomic mRNAs are synthesized in the cytoplasm of the host cell. The mRNAs are composed of leader and body sequences which are non-contiguous on the genome and are fused together in the cytoplasm by a mechanism which appears to involve...

Descripción completa

Detalles Bibliográficos
Autores principales: Spaan, W, Delius, H, Skinner, M, Armstrong, J, Rottier, P, Smeekens, S, van der Zeijst, B A, Siddell, S G
Formato: Texto
Lenguaje:English
Publicado: 1983
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC555368/
https://www.ncbi.nlm.nih.gov/pubmed/6196191
_version_ 1782122530200354816
author Spaan, W
Delius, H
Skinner, M
Armstrong, J
Rottier, P
Smeekens, S
van der Zeijst, B A
Siddell, S G
author_facet Spaan, W
Delius, H
Skinner, M
Armstrong, J
Rottier, P
Smeekens, S
van der Zeijst, B A
Siddell, S G
author_sort Spaan, W
collection PubMed
description Positive-stranded genomic RNA of coronavirus MHV and its six subgenomic mRNAs are synthesized in the cytoplasm of the host cell. The mRNAs are composed of leader and body sequences which are non-contiguous on the genome and are fused together in the cytoplasm by a mechanism which appears to involve an unusual and specific 'polymerase jumping' event.
format Text
id pubmed-555368
institution National Center for Biotechnology Information
language English
publishDate 1983
record_format MEDLINE/PubMed
spelling pubmed-5553682005-04-27 Coronavirus mRNA synthesis involves fusion of non-contiguous sequences. Spaan, W Delius, H Skinner, M Armstrong, J Rottier, P Smeekens, S van der Zeijst, B A Siddell, S G EMBO J Research Article Positive-stranded genomic RNA of coronavirus MHV and its six subgenomic mRNAs are synthesized in the cytoplasm of the host cell. The mRNAs are composed of leader and body sequences which are non-contiguous on the genome and are fused together in the cytoplasm by a mechanism which appears to involve an unusual and specific 'polymerase jumping' event. 1983 /pmc/articles/PMC555368/ /pubmed/6196191 Text en
spellingShingle Research Article
Spaan, W
Delius, H
Skinner, M
Armstrong, J
Rottier, P
Smeekens, S
van der Zeijst, B A
Siddell, S G
Coronavirus mRNA synthesis involves fusion of non-contiguous sequences.
title Coronavirus mRNA synthesis involves fusion of non-contiguous sequences.
title_full Coronavirus mRNA synthesis involves fusion of non-contiguous sequences.
title_fullStr Coronavirus mRNA synthesis involves fusion of non-contiguous sequences.
title_full_unstemmed Coronavirus mRNA synthesis involves fusion of non-contiguous sequences.
title_short Coronavirus mRNA synthesis involves fusion of non-contiguous sequences.
title_sort coronavirus mrna synthesis involves fusion of non-contiguous sequences.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC555368/
https://www.ncbi.nlm.nih.gov/pubmed/6196191
work_keys_str_mv AT spaanw coronavirusmrnasynthesisinvolvesfusionofnoncontiguoussequences
AT deliush coronavirusmrnasynthesisinvolvesfusionofnoncontiguoussequences
AT skinnerm coronavirusmrnasynthesisinvolvesfusionofnoncontiguoussequences
AT armstrongj coronavirusmrnasynthesisinvolvesfusionofnoncontiguoussequences
AT rottierp coronavirusmrnasynthesisinvolvesfusionofnoncontiguoussequences
AT smeekenss coronavirusmrnasynthesisinvolvesfusionofnoncontiguoussequences
AT vanderzeijstba coronavirusmrnasynthesisinvolvesfusionofnoncontiguoussequences
AT siddellsg coronavirusmrnasynthesisinvolvesfusionofnoncontiguoussequences

Ejemplares similares