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A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca(2+)-activated Cl(−) current when transfected into HEK293
BACKGROUND: CLCA is a family of metalloproteases that regulate Ca(2+)-activated Cl(−) fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dependent Ca(2+)-activated Cl(−) current. Motif architecture similarity wit...
Autores principales: | Mura, Casilda V., Delgado, Ricardo, Delgado, María Graciela, Restrepo, Diego, Bacigalupo, Juan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553735/ https://www.ncbi.nlm.nih.gov/pubmed/28800723 http://dx.doi.org/10.1186/s12868-017-0379-7 |
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