Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury

The mechanism of bile acid induced cholestatic liver injury remains controversial, thus hindering the development of new therapies for these diseases. In this research highlight, we briefly review the evolution of our understanding of the pathogenesis of bile acid induced liver injury, and summarize...

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Detalles Bibliográficos
Autores principales: Cai, Shi-Ying, Boyer, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553904/
https://www.ncbi.nlm.nih.gov/pubmed/28804737
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author Cai, Shi-Ying
Boyer, James L.
author_facet Cai, Shi-Ying
Boyer, James L.
author_sort Cai, Shi-Ying
collection PubMed
description The mechanism of bile acid induced cholestatic liver injury remains controversial, thus hindering the development of new therapies for these diseases. In this research highlight, we briefly review the evolution of our understanding of the pathogenesis of bile acid induced liver injury, and summarize our recent findings on this topic. Our data suggests that under pathophysiological conditions bile acid induced liver injury is mediated by inflammatory responses that are initiated from stressed hepatocytes. We conclude by mentioning potential new therapeutic approaches for treating cholestatic liver injury based on these pathophysiologic concepts.
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spelling pubmed-55539042017-08-11 Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury Cai, Shi-Ying Boyer, James L. Inflamm Cell Signal Article The mechanism of bile acid induced cholestatic liver injury remains controversial, thus hindering the development of new therapies for these diseases. In this research highlight, we briefly review the evolution of our understanding of the pathogenesis of bile acid induced liver injury, and summarize our recent findings on this topic. Our data suggests that under pathophysiological conditions bile acid induced liver injury is mediated by inflammatory responses that are initiated from stressed hepatocytes. We conclude by mentioning potential new therapeutic approaches for treating cholestatic liver injury based on these pathophysiologic concepts. 2017-06-19 2017 /pmc/articles/PMC5553904/ /pubmed/28804737 Text en http://creativecommons.org/licenses/by/4.0/ Licensed under a Creative Commons Attribution 4.0 International License which allows users including authors of articles to copy and redistribute the material in any medium or format, in addition to remix, transform, and build upon the material for any purpose, even commercially, as long as the author and original source are properly cited or credited.
spellingShingle Article
Cai, Shi-Ying
Boyer, James L.
Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury
title Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury
title_full Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury
title_fullStr Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury
title_full_unstemmed Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury
title_short Studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury
title_sort studies on the mechanisms of bile acid initiated hepatic inflammation in cholestatic liver injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553904/
https://www.ncbi.nlm.nih.gov/pubmed/28804737
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AT boyerjamesl studiesonthemechanismsofbileacidinitiatedhepaticinflammationincholestaticliverinjury

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