Structural Properties of Human IAPP Dimer in Membrane Environment Studied by All-Atom Molecular Dynamics Simulations

The aggregation of human islet amyloid polypeptide (hIAPP) can damage the membrane of the β-cells in the pancreatic islets and induce type 2 diabetes (T2D). Growing evidences indicated that the major toxic species are small oligomers of IAPP. Due to the fast aggregation nature, it is hard to charact...

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Detalles Bibliográficos
Autores principales: Liu, Na, Duan, Mojie, Yang, Minghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554177/
https://www.ncbi.nlm.nih.gov/pubmed/28801684
http://dx.doi.org/10.1038/s41598-017-08504-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554177/
https://www.ncbi.nlm.nih.gov/pubmed/28801684
http://dx.doi.org/10.1038/s41598-017-08504-x

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