Cargando…

Statistical characterization of therapeutic protein modifications

Peptide mapping with liquid chromatography–tandem mass spectrometry (LC-MS/MS) is an important analytical method for characterization of post-translational and chemical modifications in therapeutic proteins. Despite its importance, there is currently no consensus on the statistical analysis of the r...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tsai, Tsung-Heng, Hao, Zhiqi, Hong, Qiuting, Moore, Benjamin, Stella, Cinzia, Zhang, Jeffrey H., Chen, Yan, Kim, Michael, Koulis, Theo, Ryslik, Gregory A., Verschueren, Erik, Jacobson, Fred, Haskins, William E., Vitek, Olga
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554216/ https://www.ncbi.nlm.nih.gov/pubmed/28801661 http://dx.doi.org/10.1038/s41598-017-08333-y

Ejemplares similares

MSstatsPTM: Statistical Relative Quantification of Posttranslational Modifications in Bottom-Up Mass Spectrometry-Based Proteomics
por: Kohler, Devon, et al.
Publicado: (2022)

Leading a Statistical Bioinformatics Lab: It's All About Finding Balance
por: Vitek, Olga
Publicado: (2013)

Systematic LC/MS/MS Investigations for the IND-Enabling Extended Characterization of Antibody–Drug Conjugate Modifications
por: Linz, Thomas, et al.
Publicado: (2018)

MSstats Version 4.0: Statistical Analyses of Quantitative Mass Spectrometry-Based Proteomic Experiments with Chromatography-Based Quantification at Scale
por: Kohler, Devon, et al.
Publicado: (2023)

A statistical model-building perspective to identification of MS/MS spectra with PeptideProphet
por: Ma, Kelvin, et al.
Publicado: (2012)

Leveraging protein quaternary structure to identify oncogenic driver mutations
por: Ryslik, Gregory A., et al.
Publicado: (2016)

Statistical protein quantification and significance analysis in label-free LC-MS experiments with complex designs
por: Clough, Timothy, et al.
Publicado: (2012)

A graph theoretic approach to utilizing protein structure to identify non-random somatic mutations
por: Ryslik, Gregory A, et al.
Publicado: (2014)

Utilizing protein structure to identify non-random somatic mutations
por: Ryslik, Gregory A, et al.
Publicado: (2013)

Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response
por: Maculins, Timurs, et al.
Publicado: (2021)

MassIVE.quant: a community resource of quantitative mass spectrometry-based proteomics datasets
por: Choi, Meena, et al.
Publicado: (2020)

Statistical density modification with non-crystallographic symmetry
por: Terwilliger, Thomas C.
Publicado: (2002)

Observation of the modification of quantum statistics of plasmonic systems
por: You, Chenglong, et al.
Publicado: (2021)

MSstatsTMT: Statistical Detection of Differentially Abundant Proteins in Experiments with Isobaric Labeling and Multiple Mixtures
por: Huang, Ting, et al.
Publicado: (2020)

Non-degradative Ubiquitination of Protein Kinases
por: Ball, K. Aurelia, et al.
Publicado: (2016)

Cardinal: an R package for statistical analysis of mass spectrometry-based imaging experiments
por: Bemis, Kyle D., et al.
Publicado: (2015)

Statistical elimination of spectral features with large between-run variation enhances quantitative protein-level conclusions in experiments with data-independent spectral acquisition
por: Cheng, Lin-Yang, et al.
Publicado: (2015)

Statistical density modification using local pattern matching
por: Terwilliger, Thomas C.
Publicado: (2003)

Comparative efficacy of surgical approaches to disease modification in Parkinson disease
por: Rahimpour, Shervin, et al.
Publicado: (2022)

A spatial simulation approach to account for protein structure when identifying non-random somatic mutations
por: Ryslik, Gregory A, et al.
Publicado: (2014)

Getting Started in Computational Mass Spectrometry–Based Proteomics
por: Vitek, Olga
Publicado: (2009)

Premalignant lesions and gastric cancer: Current understanding
por: Koulis, Athanasios, et al.
Publicado: (2019)

General statistics
por: Chase, Warren, et al.
Publicado: (1997)

General statistics
por: Chase, Warren, et al.
Publicado: (2000)

Implementation of a Computerized Screening Inventory: Improved Usability Through Iterative Testing and Modification
por: Boudreaux, Edwin D, et al.
Publicado: (2016)

A review of modification of carbon electrode material in capacitive deionization
por: Cheng, Yutuo, et al.
Publicado: (2019)

Statistics : concepts and controversies /
por: Moore, David S.
Publicado: (1979)

HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma
por: Quan, Lina, et al.
Publicado: (2022)

Workshop on Model Uncertainty and its Statistical Implications
por: Dijkstra, Theo
Publicado: (1988)

Unsupervised segmentation of mass spectrometric ion images characterizes morphology of tissues
por: Guo, Dan, et al.
Publicado: (2019)

Correction: HNRNPA2B1-mediated m6A modification of TLR4 mRNA promotes progression of multiple myeloma
por: Jia, Chuiming, et al.
Publicado: (2023)

Computational Mass Spectrometry–Based Proteomics
por: Käll, Lukas, et al.
Publicado: (2011)

Modification of polymers
por: Carraher, Charles, et al.
Publicado: (1983)

Hypofractionated whole breast radiotherapy: current perspectives
por: Koulis, Theodora A, et al.
Publicado: (2015)

Numerical Modelling of the Ultrasonic Treatment of Aluminium Melts: An Overview of Recent Advances
por: Lebon, Bruno, et al.
Publicado: (2019)

Comparison of frequency domain and time domain methods for the numerical simulation of contactless ultrasonic cavitation
por: Beckwith, Christopher, et al.
Publicado: (2022)

The statistical sleuth : a course in methods of data analysis /
por: Ramsey, Fred L.
Publicado: (2002)

Post-translational modifications and stress adaptation: the paradigm of FKBP51
por: Rein, Theo
Publicado: (2020)

The basic practice of statistics /
por: Moore, David S.
Publicado: (2000)

Statistics: concepts and controversies
por: Moore, David S
Publicado: (1985)

Cannot write session to /tmp/vufind_sessions/sess_rb86kgligip35htrtpjtmj7ve7